{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:20:35Z","timestamp":1790698835915,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tonsillar infection with Streptococcus pyogenes may induce several nonsuppurative autoimmune sequelae. The precise pathogenetic mechanisms behind this clinically well-established association are still unresolved. Using TCR analysis, we sought to identify a link between streptococcal tonsillitis and the T cell-mediated autoimmune response in psoriasis. Three patients with streptococcal-induced psoriasis underwent tonsillectomy. Using size spectratyping and sequencing of TCR \u03b2-chain variable region gene (TCRBV) rearrangements, we compared the TCR usage of psoriatic skin lesions, blood, tonsils, and tonsillar T cells fractionated according to the expression of the skin addressin \u201ccutaneous lymphocyte-associated Ag\u201d (CLA). TCRBV-size spectratype analysis of the blood lymphocytes, tonsils, and the CLA-negative tonsillar T cells revealed largely unselected T cell populations. Instead, TCRBV gene families of the psoriatic lesions and skin-homing CLA-positive tonsillar T cells displayed highly restricted spectratypes. Sequencing of TCRBV cDNA identified various clonal TCRBV rearrangements within the psoriatic lesions that indicated Ag-driven T cell expansion. Several of these clonotypes were also detected within the tonsils and, in one of the patients, within the small subset of CLA-positive tonsillar T cells, suggesting that T cells from the same T cell clones were simultaneously present within skin and tonsillar tissue. Because after tonsillectomy psoriasis cleared in all three patients our observations indicate that T cells may connect psoriatic inflammation to streptococcal angina. They suggest that the chronic streptococcal immune stimulus within the tonsils could act as a source for pathogenic T cells in poststreptococcal disorders, and they may help to explain why eliminating this source with tonsillectomy may improve streptococcal-induced sequelae.<\/jats:p>","DOI":"10.4049\/jimmunol.176.11.7104","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:47:30Z","timestamp":1398023250000},"page":"7104-7111","source":"Crossref","is-referenced-by-count":127,"title":["Identical TCR \u03b2-Chain Rearrangements in Streptococcal Angina and Skin Lesions of Patients with Psoriasis Vulgaris"],"prefix":"10.1093","volume":"176","author":[{"given":"Laura","family":"Diluvio","sequence":"first","affiliation":[{"name":"Department of Dermatology, Ludwig-Maximilians-University of Munich , Munich ,","place":["Germany"]},{"name":"Department of Dermatology, University of Rome \u201cTor Vergata\u201d , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Vollmer","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ludwig-Maximilians-University of Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Besgen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ludwig-Maximilians-University of Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim W","family":"Ellwart","sequence":"additional","affiliation":[{"name":"Institute for Molecular Immunology, GSF-Research Center for Environment and Health , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Chimenti","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Rome \u201cTor Vergata\u201d , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg C","family":"Prinz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ludwig-Maximilians-University of Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,6,1]]},"reference":[{"key":"2026020212030130200_R1","first-page":"13","volume-title":"J. 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