{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:06:52Z","timestamp":1791176812659,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CARMA1 has been shown to be important for Ag-stimulated activation of NF-\u03baB in lymphocytes in vitro and thus could be a novel therapeutic target in inflammatory diseases such as asthma. In the present study, we demonstrate that mice with deletion in the CARMA1 gene (CARMA1\u2212\/\u2212) do not develop inflammation in a murine model of asthma. Compared with wild-type controls, CARMA1\u2212\/\u2212 mice did not develop airway eosinophilia, had no significant T cell recruitment into the airways, and had no evidence for T cell activation in the lung or draining lymph nodes. In addition, the CARMA1\u2212\/\u2212 mice had significantly decreased levels of IL-4, IL-5, and IL-13, did not produce IgE, and did not develop airway hyperresponsiveness or mucus cell hypertrophy. However, adoptive transfer of wild-type Th2 cells into CARMA1\u2212\/\u2212 mice restored eosinophilic airway inflammation, cytokine production, airway hyperresponsiveness, and mucus production. This is the first demonstration of an in vivo role for CARMA1 in a disease process. Furthermore, the data clearly show that CARMA1 is essential for the development of allergic airway inflammation through its role in T lymphocytes, and may provide a novel means to inhibit NF-\u03baB for therapy in asthma.<\/jats:p>","DOI":"10.4049\/jimmunol.176.12.7272","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:09:47Z","timestamp":1397848187000},"page":"7272-7277","source":"Crossref","is-referenced-by-count":35,"title":["CARMA1 Is Critical for the Development of Allergic Airway Inflammation in a Murine Model of Asthma"],"prefix":"10.1093","volume":"176","author":[{"given":"Benjamin D","family":"Medoff","sequence":"first","affiliation":[{"name":"Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School , Charlestown, MA 02129"},{"name":"Pulmonary and Critical Care Unit, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Seed","sequence":"additional","affiliation":[{"name":"Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Jackobek","sequence":"additional","affiliation":[{"name":"Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School , Charlestown, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Zora","sequence":"additional","affiliation":[{"name":"Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School , Charlestown, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D","family":"Luster","sequence":"additional","affiliation":[{"name":"Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School , Charlestown, MA 02129"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramnik","family":"Xavier","sequence":"additional","affiliation":[{"name":"Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114"},{"name":"Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,6,15]]},"reference":[{"key":"2026020214090971400_R1","first-page":"11877","volume-title":"J. 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