{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:25:33Z","timestamp":1790911533506,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-23, a heterodimeric cytokine composed of the p40 subunit of IL-12 and a novel p19 subunit, has been shown to be a key player in models of autoimmune chronic inflammation. To investigate the role of IL-23 in host resistance during chronic fungal infection, wild-type, IL-12- (IL-12p35\u2212\/\u2212), IL-23- (IL-23p19\u2212\/\u2212), and IL-12\/IL-23- (p40-deficient) deficient mice on a C57BL\/6 background were infected with Cryptococcus neoformans. Following infection, p40-deficient mice demonstrated higher mortality than IL-12p35\u2212\/\u2212 mice. Reconstitution of p40-deficient mice with rIL-23 prolonged their survival to levels similar to IL-12p35\u2212\/\u2212 mice. IL-23p19\u2212\/\u2212 mice showed a moderately reduced survival time and delayed fungal clearance in the liver. Although IFN-\u03b3 production was similar in wild-type and IL-23p19\u2212\/\u2212 mice, production of IL-17 was strongly impaired in the latter. IL-23p19\u2212\/\u2212 mice produced fewer hepatic granulomata relative to organ burden and showed defective recruitment of mononuclear cells to the brain. Moreover, activation of microglia cells and expression of IL-1\u03b2, IL-6, and MCP-1 in the brain was impaired. These results show that IL-23 complements the more dominant role of IL-12 in protection against a chronic fungal infection by an enhanced inflammatory cell response and distinct cytokine regulation.<\/jats:p>","DOI":"10.4049\/jimmunol.176.2.1098","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:43:16Z","timestamp":1398022996000},"page":"1098-1106","source":"Crossref","is-referenced-by-count":195,"title":["IL-23 Enhances the Inflammatory Cell Response in\n                    <i>Cryptococcus neoformans<\/i>\n                    Infection and Induces a Cytokine Pattern Distinct from IL-12"],"prefix":"10.1093","volume":"176","author":[{"given":"Melanie A","family":"Kleinschek","sequence":"first","affiliation":[{"name":"Institute of Immunology, College of Veterinary Medicine, University of Leipzig , Leipzig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Muller","sequence":"additional","affiliation":[{"name":"Institute of Immunology, College of Veterinary Medicine, University of Leipzig , Leipzig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J","family":"Brodie","sequence":"additional","affiliation":[{"name":"Department of Drug Safety and Metabolism, Schering-Plough Research Institute , Lafayette, NJ 07848"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Stenzel","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, Medical Faculty, University of Cologne , Cologne ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Kohler","sequence":"additional","affiliation":[{"name":"Gerhard Domagk Institute of Pathology, University of Muenster , Muenster ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy M","family":"Blumenschein","sequence":"additional","affiliation":[{"name":"Experimental Pathology and Pharmacology, DNAX Research , Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard K","family":"Straubinger","sequence":"additional","affiliation":[{"name":"Institute of Immunology, College of Veterinary Medicine, University of Leipzig , Leipzig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrill","family":"McClanahan","sequence":"additional","affiliation":[{"name":"Experimental Pathology and Pharmacology, DNAX Research , Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Kastelein","sequence":"additional","affiliation":[{"name":"Discovery Research, DNAX Research , Palo Alto, CA 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gottfried","family":"Alber","sequence":"additional","affiliation":[{"name":"Institute of Immunology, College of Veterinary Medicine, University of Leipzig , Leipzig ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,1,15]]},"reference":[{"key":"2026020211335081700_R1","first-page":"715","volume-title":"Immunity","year":"2000"},{"key":"2026020211335081700_R2","first-page":"207","volume-title":"Trends Immunol.","year":"2003"},{"key":"2026020211335081700_R3","first-page":"641","volume-title":"Immunity","year":"2003"},{"key":"2026020211335081700_R4","first-page":"14002","volume-title":"Proc. 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