{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T04:41:16Z","timestamp":1770093676474,"version":"3.49.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IFN-\u03b3 promotes the development of lymphocytic spontaneous autoimmune thyroiditis (L-SAT) in NOD.H-2h4 mice and inhibits the development of thyrocyte hyperplasia and proliferation (TEC H\/P). The precise mechanisms by which IFN-\u03b3 promotes L-SAT and inhibits TEC H\/P are unknown. To determine whether responsiveness of lymphocytes or thyrocytes to IFN-\u03b3 is important for the development of these lesions, IFN-\u03b3R\u2212\/\u2212 mice, which develop TEC H\/P similar to IFN-\u03b3\u2212\/\u2212 mice, were used as recipients for adoptive cell transfer. Wild-type (WT) splenocytes or bone marrow induced L-SAT and inhibited TEC H\/P in IFN-\u03b3\u2212\/\u2212, but not IFN-\u03b3R\u2212\/\u2212 recipients. IFN-\u03b3R\u2212\/\u2212 recipients of WT cells developed severe TEC H\/P, but did not develop L-SAT, suggesting that thyrocytes responding to IFN-\u03b3 are important for inhibition of TEC H\/P. Unexpectedly, IFN-\u03b3R\u2212\/\u2212 splenocytes or bone marrow did not induce L-SAT in IFN-\u03b3\u2212\/\u2212 or WT mice even though IFN-\u03b3R\u2212\/\u2212 lymphocyte donors produced as much IFN-\u03b3 as lymphocytes from WT donors, and thyrocytes could respond to IFN-\u03b3. Real-time PCR indicated that recipients of IFN-\u03b3R\u2212\/\u2212 bone marrow expressed less mRNA for IFN-\u03b3-inducible chemokines compared with recipients of WT bone marrow. This might limit the migration of IFN-\u03b3R\u2212\/\u2212 lymphocytes to thyroids. Few IFN-\u03b3R\u2212\/\u2212 lymphocytes infiltrated thyroids even in the presence of WT lymphocytes, suggesting that lymphocytes unable to respond to IFN-\u03b3 are not induced to migrate to thyroids. These results suggest that thyrocytes must be able to respond to IFN-\u03b3 for the development of L-SAT and inhibition of TEC H\/P, and lymphocytes must be able to respond to IFN-\u03b3 to induce L-SAT.<\/jats:p>","DOI":"10.4049\/jimmunol.176.2.1259","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:43:16Z","timestamp":1398022996000},"page":"1259-1265","source":"Crossref","is-referenced-by-count":27,"title":["Thyrocytes Responding to IFN-\u03b3 Are Essential for Development of Lymphocytic Spontaneous Autoimmune Thyroiditis and Inhibition of Thyrocyte Hyperplasia"],"prefix":"10.1093","volume":"176","author":[{"given":"Shiguang","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Missouri School of Medicine , Columbia, MO 65212"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon C","family":"Sharp","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Missouri School of Medicine , Columbia, MO 65212"},{"name":"Department of Pathology, University of Missouri School of Medicine , Columbia, MO 65212"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Braley-Mullen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Missouri School of Medicine , Columbia, MO 65212"},{"name":"Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine , Columbia, MO 65212"},{"name":"Department of Veterans Affairs, Research Service , Columbia, MO 65212"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,1,15]]},"reference":[{"key":"2026020211320551900_R1","first-page":"287","volume-title":"Clin. Immunol. Immunopathol.","year":"1996"},{"key":"2026020211320551900_R2","first-page":"157","volume-title":"J. Autoimmun.","year":"1999"},{"key":"2026020211320551900_R3","first-page":"1191","volume-title":"Eur. J. Immunol.","year":"2000"},{"key":"2026020211320551900_R4","first-page":"97","volume-title":"Autoimmun. Rev.","year":"2002"},{"key":"2026020211320551900_R5","first-page":"3999","volume-title":"J. Immunol.","year":"2002"},{"key":"2026020211320551900_R6","first-page":"563","volume-title":"Annu. Rev. Immunol.","year":"1997"},{"key":"2026020211320551900_R7","first-page":"1941","volume-title":"N. Engl. J. Med.","year":"1996"},{"key":"2026020211320551900_R8","first-page":"95","volume-title":"Cytokine Growth Factor Rev.","year":"2002"},{"key":"2026020211320551900_R9","first-page":"5523","volume-title":"J. Immunol.","year":"2003"},{"key":"2026020211320551900_R10","first-page":"275","volume-title":"Eur. J. Immunol.","year":"1993"},{"key":"2026020211320551900_R11","first-page":"2219","volume-title":"J. Immunol.","year":"1992"},{"key":"2026020211320551900_R12","first-page":"5105","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020211320551900_R13","first-page":"201","volume-title":"Eur. J. Immunol.","year":"1998"},{"key":"2026020211320551900_R14","first-page":"501","volume-title":"Int. Rev. Immunol.","year":"2000"},{"key":"2026020211320551900_R15","first-page":"1719","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2000"},{"key":"2026020211320551900_R16","first-page":"793","volume-title":"J. Exp. Med.","year":"1993"},{"key":"2026020211320551900_R17","first-page":"2007","volume-title":"Diabetes","year":"2000"},{"key":"2026020211320551900_R18","first-page":"679","volume-title":"Int. Immunol.","year":"1997"},{"key":"2026020211320551900_R19","first-page":"716","volume-title":"J. Leukocyte Biol.","year":"2005"},{"key":"2026020211320551900_R20","first-page":"37","volume-title":"J. Autoimmun.","year":"2001"},{"key":"2026020211320551900_R21","first-page":"472","volume-title":"Exp. Neurol.","year":"2001"},{"key":"2026020211320551900_R22","first-page":"6637","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020211320551900_R23","first-page":"447","volume-title":"J. Exp. Med.","year":"2004"},{"key":"2026020211320551900_R24","first-page":"749","volume-title":"Ann. Rev. Immunol.","year":"1997"},{"key":"2026020211320551900_R25","first-page":"3399","volume-title":"Cancer Res.","year":"2001"},{"key":"2026020211320551900_R26","first-page":"7617","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020211320551900_R27","first-page":"2759","volume-title":"J. Immunol.","year":"2000"},{"key":"2026020211320551900_R28","first-page":"4878","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020211320551900_R29","first-page":"331","volume-title":"J. Leukocyte Biol.","year":"2001"},{"key":"2026020211320551900_R30","first-page":"155","volume-title":"Exp. Mol. Pathol.","year":"2002"},{"key":"2026020211320551900_R31","first-page":"9","volume-title":"Autoimmunity","year":"1996"},{"key":"2026020211320551900_R32"},{"key":"2026020211320551900_R33","first-page":"719","volume-title":"Science","year":"1996"},{"key":"2026020211320551900_R34","first-page":"7673","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1996"},{"key":"2026020211320551900_R35","first-page":"5328","volume-title":"Mol. Cell. Biol.","year":"1997"},{"key":"2026020211320551900_R36","first-page":"96","volume-title":"Trends Immunol.","year":"2002"},{"key":"2026020211320551900_R37","first-page":"23","volume-title":"Trends Endocrinol. Metab.","year":"2002"},{"key":"2026020211320551900_R38","first-page":"143","volume-title":"Am. J. Clin. Pathol.","year":"2002"},{"key":"2026020211320551900_R39","first-page":"141","volume-title":"Int. J. Surg. Pathol.","year":"2002"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/176\/2\/1259\/62633897\/1259.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/176\/2\/1259\/62633897\/1259.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T16:32:14Z","timestamp":1770049934000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/176\/2\/1259\/8034190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":39,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2006,1,15]]},"published-print":{"date-parts":[[2006,1,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.176.2.1259","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2006,1]]},"published":{"date-parts":[[2006,1]]}}}