{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T08:20:58Z","timestamp":1770106858736,"version":"3.49.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Heat shock proteins (Hsp) are markedly up-regulated at sites of inflammation during autoimmune diseases like experimental autoimmune encephalomyelitis (EAE). In this study, we show that Hsp70-peptide complexes (pc) isolated from brains of mice with EAE prevented the development of EAE clinically and pathologically when administered before proteolipid protein 139\u2013151 (PLP139\u2013151) immunization. In contrast, pure Hsp70 or Hsp70-pc derived from brains of healthy mice or other inflamed tissue did not modulate the expression of EAE. In animals in which EAE had been suppressed by Hsp70-pc, lymphocytes showed increased cell death in response to PLP139\u2013151 that correlated with elevated IFN-\u03b3 and NO production. Coculture of spleen cells from Hsp70-pc immunized mice with spleen cells from untreated EAE mice, in addition to depletion experiments, showed that NK cells reduced reactivity to PLP139\u2013151. Transfer of NK cells from Hsp70-pc-immunized mice to recipients sensitized for EAE abolished disease development. Thus, we propose that Hsp70 demonstrate the ability to bind to peptides generated during brain inflammation and to induce a regulatory NK cell population that is capable of preventing subsequent autoimmunization for EAE.<\/jats:p>","DOI":"10.4049\/jimmunol.176.3.1588","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T18:20:05Z","timestamp":1398018005000},"page":"1588-1599","source":"Crossref","is-referenced-by-count":29,"title":["Brain-Derived Heat Shock Protein 70-Peptide Complexes Induce NK Cell-Dependent Tolerance to Experimental Autoimmune Encephalomyelitis"],"prefix":"10.1093","volume":"176","author":[{"given":"Grazyna","family":"Galazka","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical University of Lodz , Lodz ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariusz","family":"Stasiolek","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Lodz , Lodz ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Walczak","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Lodz , Lodz ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Jurewicz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Lodz , Lodz ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicja","family":"Zylicz","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, International Institute of Molecular and Cell Biology , Warsaw ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia F","family":"Brosnan","sequence":"additional","affiliation":[{"name":"Department of Pathology (Neuropathology), Neurology and Neuroscience, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cedric S","family":"Raine","sequence":"additional","affiliation":[{"name":"Department of Pathology (Neuropathology), Neurology and Neuroscience, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof W","family":"Selmaj","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Lodz , Lodz ,","place":["Poland"]},{"name":"Department of Pathology (Neuropathology), Neurology and Neuroscience, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,2,1]]},"reference":[{"key":"2026020214080248500_R1","first-page":"3212","volume-title":"J. 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