{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:33:04Z","timestamp":1791282784256,"version":"4.1.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We investigated the role of B cell Ag presentation in homeostasis of the memory B cell compartment in a mouse model where a conditional allele for the \u03b2-chain of MHC class II (MHC-II) is deleted in the vast majority of all B cells by cd19 promoter-mediated expression of Cre recombinase (IA-B mice). Upon T cell-dependent immunization, a small number of MHC-II+ B cells in IA-B mice dramatically expanded and restored normal albeit delayed levels of germinal center (GC) B cells with an affinity-enhancing somatic mutation to Ag. IA-B mice also established normal levels of MHC-II+ memory B cells, which, however, subsequently lost MHC-II expression by ongoing deletion of the conditional iab allele without significant loss in their number. Furthermore, in vivo Ag restimulation of MHC-II\u2212 memory B cells of IA-B mice failed to cause differentiation into plasma cells (PCs), even in the presence of Ag-specific CD4+ T cells. In addition, both numbers and Ag-specific affinity of long-lived PCs during the late post-GC phase, as well as post-GC serum affinity maturation, were significantly reduced in IA-B mice. These results support a notion that MHC-II-dependent T cell help during post-GC phase is not absolutely required for the maintenance of memory B cell frequency but is important for their differentiation into PCs and for the establishment of the long-lived PC compartment.<\/jats:p>","DOI":"10.4049\/jimmunol.176.4.2122","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T20:31:56Z","timestamp":1398025916000},"page":"2122-2133","source":"Crossref","is-referenced-by-count":39,"title":["Role of MHC Class II on Memory B Cells in Post-Germinal Center B Cell Homeostasis and Memory Response"],"prefix":"10.1093","volume":"176","author":[{"given":"Michiko","family":"Shimoda","sequence":"first","affiliation":[{"name":"Program in Molecular Immunology, Immunotherapy Center, Medical College of Georgia , Augusta, GA 30912"},{"name":"Department of Pathology, Medical College of Georgia , Augusta, GA 30912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Program in Molecular Immunology, Immunotherapy Center, Medical College of Georgia , Augusta, GA 30912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanene P S","family":"Pihkala","sequence":"additional","affiliation":[{"name":"Program in Molecular Immunology, Immunotherapy Center, Medical College of Georgia , Augusta, GA 30912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pandelakis A","family":"Koni","sequence":"additional","affiliation":[{"name":"Program in Molecular Immunology, Immunotherapy Center, Medical College of Georgia , Augusta, GA 30912"},{"name":"Department of Medicine, Medical College of Georgia , Augusta, GA 30912"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,2,15]]},"reference":[{"key":"2026020211394180500_R1","first-page":"355","volume-title":"Eur. 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