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A small number of naive Ag-specific CD4+ T cells were found in nonlymphoid tissues and, in the 8 days following infection, the number of activated cells increased in all tissues analyzed, and their effector functions matured. Finally, we show that a naive mouse contains \u223c100 naive CD4+ precursor cells specific for a single epitope, a precursor frequency of \u223c10\u22125, similar to that of naive CD8+ T cells, indicating that the \u223c50-fold difference in size of the two responses to virus infection is determined by something other than the number of precursor cells.<\/jats:p>","DOI":"10.4049\/jimmunol.176.5.3028","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T19:49:01Z","timestamp":1398282541000},"page":"3028-3036","source":"Crossref","is-referenced-by-count":61,"title":["Precursor Frequency, Nonlinear Proliferation, and Functional Maturation of Virus-Specific CD4+ T Cells"],"prefix":"10.1093","volume":"176","author":[{"given":"Jason K","family":"Whitmire","sequence":"first","affiliation":[{"name":"Department of Neuropharmacology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Benning","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Lindsay","family":"Whitton","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, The Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,3,1]]},"reference":[{"key":"2026020211395153400_R1","first-page":"134","volume-title":"Cell. 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