{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:20:34Z","timestamp":1791206434612,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The action of type I IFN (IFN-I) on APCs is well studied, but their direct effect on CD4 T cells is unclear. To address this, we transferred IFN-I receptor-deficient (IFN-IR0) and -sufficient (wild-type, WT) TCR-transgenic CD4 T cells into WT mice and analyzed their response to immunization. In response to lymphocytic choriomeningitis virus immunization, WT CD4 T cells expanded \u223c100-fold, whereas IFN-IR0 CD4 T cells expanded &amp;lt;10-fold. However, both WT and IFN-IR0 CD4 T cells expanded \u223c10-fold after Listeria monocytogenes immunization. Poor expansion of IFN-IR0 CD4 T cells after lymphocytic choriomeningitis virus immunization was not due to a defect in proliferation or initial activation but to poor survival of the daughter cells. Thus, direct IFN-I signals can play either a critical or minimal role in CD4 T cell clonal expansion depending on the specific pathogen.<\/jats:p>","DOI":"10.4049\/jimmunol.176.6.3315","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:34:33Z","timestamp":1398022473000},"page":"3315-3319","source":"Crossref","is-referenced-by-count":175,"title":["Cutting Edge: The Direct Action of Type I IFN on CD4 T Cells Is Critical for Sustaining Clonal Expansion in Response to a Viral but Not a Bacterial Infection"],"prefix":"10.1093","volume":"176","author":[{"given":"Colin","family":"Havenar-Daughton","sequence":"first","affiliation":[{"name":"Department of Immunology and Washington National Primate Center, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh A","family":"Kolumam","sequence":"additional","affiliation":[{"name":"Department of Immunology and Washington National Primate Center, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaja","family":"Murali-Krishna","sequence":"additional","affiliation":[{"name":"Department of Immunology and Washington National Primate Center, University of Washington , Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,3,15]]},"reference":[{"key":"2026020214080441500_R1","first-page":"227","volume-title":"Annu. 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