{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T21:05:24Z","timestamp":1770152724078,"version":"3.49.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The spontaneous crescentic glomerulonephritis-forming\/Kinjoh (SCG\/Kj) mouse is a model of human crescentic glomerulonephritis and vasculitis associated with the production of the myeloperoxidase (MPO)-specific antineutrophil cytoplasmic autoantibody (MPO-ANCA). Although the disease is mediated initially by mutation of the Fas gene (lpr), SCG\/Kj mice also have non-Fas predisposing genetic factors. To define these factors, genome-wide quantitative trait locus (QTL) mapping was performed on female (B6\u00d7 SCG\/Kj) F2 intercross mice. Fourteen non-Fas QTLs were identified. QTLs of glomerulonephritis were located on chromosomes 1, 10, 13, 16, and 17, vasculitis on chromosomes 1 and 17, splenomegaly on chromosome 1, hypergammaglobulinemia on chromosomes 1, 2, 4, 6, 7, 11, 13, and 17, antinuclear Ab on chromosomes 1, 8, 10, and 12, and MPO-ANCA production on chromosomes 1 and 10. Significant QTLs derived from SCG\/Kj on chromosomes 1, 2, 7, and 13 were designated Scg-1 to Scg-5, respectively, and those derived from B6 on chromosomes 4, 6, 17, and 10 were designated Sxb-1 to Sxb-4, respectively. Two loci linked to MPO-ANCA production on chromosomes 1 and 10 were designated Man-1 and Man-2 (for MPO-ANCA), respectively. Although both Scg-1 and Scg-2 were on chromosome 1 and shared several functions, it was of interest that aberrant MPO-ANCA production was exclusively controlled by Man-1, the centromeric half region of the Scg-2 chromosomal segment. We also examined the epistatic effects between the lpr mutation and non-Fas susceptibility genes. QTLs are discussed in relation to previously described loci, with emphasis on their candidate genes.<\/jats:p>","DOI":"10.4049\/jimmunol.176.6.3662","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T19:34:33Z","timestamp":1398022473000},"page":"3662-3673","source":"Crossref","is-referenced-by-count":15,"title":["Genetic Dissection of Vasculitis, Myeloperoxidase-Specific Antineutrophil Cytoplasmic Autoantibody Production, and Related Traits in Spontaneous Crescentic Glomerulonephritis-Forming\/Kinjoh Mice"],"prefix":"10.1093","volume":"176","author":[{"given":"Yoshitomo","family":"Hamano","sequence":"first","affiliation":[{"name":"Department of Pathology, Juntendo University School of Medicine , Bunkyo-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyuki","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Department of Pathology, Juntendo University School of Medicine , Bunkyo-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Pathology, Juntendo University School of Medicine , Bunkyo-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo Dong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pathology, Juntendo University School of Medicine , Bunkyo-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Juntendo University School of Medicine , Bunkyo-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Pathology, Juntendo University School of Medicine , Bunkyo-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Pathology, Juntendo University School of Medicine , Bunkyo-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masumi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pathology, Juntendo University School of Medicine , Bunkyo-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Ishida-Okawara","sequence":"additional","affiliation":[{"name":"Biodefense Laboratory, National Institute of Infectious Diseases , Shinjuku-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Tachikawa","sequence":"additional","affiliation":[{"name":"Biodefense Laboratory, National Institute of Infectious Diseases , Shinjuku-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Toin Human Science and Technology Center, Department of Biomedical Engineering, Toin University of Yokohama , Yokohama-shi, Kanagawa ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Tokunaka","sequence":"additional","affiliation":[{"name":"Nippon Kayaku Co., Ltd. , Kita-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Pathology, Juntendo University School of Medicine , Bunkyo-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Biodefense Laboratory, National Institute of Infectious Diseases , Shinjuku-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,3,15]]},"reference":[{"key":"2026020214090257800_R1","first-page":"3413","volume-title":"Proc. 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