{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:33:24Z","timestamp":1792632804533,"version":"4.5.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic dry eye syndrome affects over 10 million people in the United States; it is associated with inflammation of the lacrimal gland (LG) and in some cases involves T cell infiltration of the conjunctiva. We demonstrate that environmental desiccating stress (DS) elicits T cell-mediated inflammation of the cornea, conjunctiva, and LG, but not other organs in mice. The lacrimal keratoconjunctivitis (LKC) was mediated by CD4+ T cells, which, when adoptively transferred to T cell-deficient nude mice, produced inflammation in the LG, cornea, and conjunctiva, but not in any other organ. Adoptively transferred CD4+ T cells produced LKC even though recipients were not exposed to DS. LKC was exacerbated in euthymic mice depleted of CD4+CD25+forkhead\/winged helix transcription factor+ regulatory T cells. The results suggest that DS exposes shared epitopes in the cornea, conjunctiva, and LG that induce pathogenic CD4+ T cells that produce LKC, which under normal circumstances is restrained by CD4+CD25+forkhead\/winged helix transcription factor+ regulatory T cells.<\/jats:p>","DOI":"10.4049\/jimmunol.176.7.3950","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:59:44Z","timestamp":1398031184000},"page":"3950-3957","source":"Crossref","is-referenced-by-count":271,"title":["Desiccating Stress Induces T Cell-Mediated Sjo\u0308gren\u2019s Syndrome-Like Lacrimal Keratoconjunctivitis"],"prefix":"10.1093","volume":"176","author":[{"given":"Jerry Y","family":"Niederkorn","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Texas Southwestern Medical Center , Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E","family":"Stern","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences , Allergan, Irvine, CA 92623"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C","family":"Pflugfelder","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Baylor College of Medicine , Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cintia S","family":"De Paiva","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Baylor College of Medicine , Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M","family":"Corrales","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Baylor College of Medicine , Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences , Allergan, Irvine, CA 92623"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karyn","family":"Siemasko","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences , Allergan, Irvine, CA 92623"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,4,1]]},"reference":[{"key":"2026020211333261400_R1","first-page":"654","volume-title":"Cornea","year":"1998"},{"key":"2026020211333261400_R2","first-page":"1489","volume-title":"Arch. Ophthalmol.","year":"2000"},{"key":"2026020211333261400_R3","first-page":"2609","volume-title":"Invest. Ophthalmol. Vis. Sci.","year":"2002"},{"key":"2026020211333261400_R4","first-page":"584","volume-title":"Cornea","year":"1998"},{"key":"2026020211333261400_R5","first-page":"631","volume-title":"Ophthalmology","year":"2000"},{"key":"2026020211333261400_R6","first-page":"3493","volume-title":"Invest. Ophthalmol. Vis. Sci.","year":"1994"},{"key":"2026020211333261400_R7","first-page":"533","volume-title":"Adv. Exp. Med. Biol.","year":"1998"},{"key":"2026020211333261400_R8","first-page":"201","volume-title":"Curr. Eye Res.","year":"1999"},{"key":"2026020211333261400_R9","first-page":"301","volume-title":"Science","year":"2002"},{"key":"2026020211333261400_R10","first-page":"965","volume-title":"Rheumatology","year":"2005"},{"key":"2026020211333261400_R11","first-page":"4293","volume-title":"Invest. Ophthalmol. Vis. Sci.","year":"2004"},{"key":"2026020211333261400_R12","first-page":"124","volume-title":"Invest. Ophthalmol. Vis. Sci.","year":"2003"},{"key":"2026020211333261400_R13","volume-title":"Diagnostic Approaches to Dry Eye and Lacrimal Keratoconjunctivitis","year":"2004"},{"key":"2026020211333261400_R14","first-page":"632","volume-title":"Invest. Ophthalmol. Vis. Sci.","year":"2002"},{"key":"2026020211333261400_R15","first-page":"18","volume-title":"Immunology","year":"2003"},{"key":"2026020211333261400_R16","first-page":"5211","volume-title":"J. Immunol.","year":"1999"},{"key":"2026020211333261400_R17","first-page":"114","volume-title":"J. Leukocyte Biol.","year":"2005"},{"key":"2026020211333261400_R18","first-page":"S211","volume-title":"Surv. Ophthalmol.","year":"2001"},{"key":"2026020211333261400_R19","first-page":"563","volume-title":"Curr. Opin. Rheumatol.","year":"2003"},{"key":"2026020211333261400_R20","first-page":"1390","volume-title":"Arthritis Rheum.","year":"2002"},{"key":"2026020211333261400_R21","first-page":"111","volume-title":"Clin. Immunol.","year":"2002"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/176\/7\/3950\/62638187\/3950.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/176\/7\/3950\/62638187\/3950.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T16:33:40Z","timestamp":1770050020000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/176\/7\/3950\/8034248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,1]]},"references-count":21,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2006,4,1]]},"published-print":{"date-parts":[[2006,4,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.176.7.3950","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2006,4]]},"published":{"date-parts":[[2006,4,1]]}}}