{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:32:04Z","timestamp":1791606724315,"version":"4.3.4"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Profound lymphopenia has been observed during many acute viral infections, and our laboratory has previously documented a type I IFN-dependent loss of CD8 T cells immediately preceding the development of the antiviral T cell response. Most memory (CD44high) and some naive (CD44low) CD8 T cells are susceptible to IFN-induced attrition, and we show in this study that the IFN-induced attrition of CD8+CD44high T cells is associated with elevated activation of caspase-3 and caspase-8. We questioned whether TCR engagement by Ag would render CD8 T cells resistant to attrition. We tested whether a high concentration of Ag (GP33 peptide) would protect lymphocytic choriomeningitis (LCMV)-specific naive CD8 T cells (TCR transgenic P14 cells specific for the GP33 epitope of LCMV) and memory CD8 T cells (GP33-specific LCMV-immune cells) from depletion. Both naive P14 and memory GP33-specific donor CD8 T cells decreased substantially 16 h after inoculation with the Toll receptor agonist and IFN inducer, poly(I:C), regardless of whether a high concentration of GP33 peptide was administered to host mice beforehand. Moreover, donor naive P14 and LCMV-specific memory cells were depleted from day 2 LCMV-infected hosts by 16 h posttransfer. These results indicate that Ag engagement does not protect CD8 T cells from the IFN-induced T cell attrition associated with viral infections. In addition, computer models indicated that early depletion of memory T cells may allow for the generation for a more diverse T cell response to infection by reducing the immunodomination caused by cross-reactive T cells.<\/jats:p>","DOI":"10.4049\/jimmunol.176.7.4284","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T01:59:44Z","timestamp":1398045584000},"page":"4284-4295","source":"Crossref","is-referenced-by-count":106,"title":["IFN-Induced Attrition of CD8 T Cells in the Presence or Absence of Cognate Antigen during the Early Stages of Viral Infections"],"prefix":"10.1093","volume":"176","author":[{"given":"Kapil","family":"Bahl","sequence":"first","affiliation":[{"name":"Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical School , Worcester, MA 01655"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Kwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Valeant Pharmaceuticals International , Costa Mesa, CA 92626"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Calcagno","sequence":"additional","affiliation":[{"name":"Department of Oncology, Biology and Genetics, University of Genoa , Genoa ,","place":["Italy"]},{"name":"Department of Rheumatology, Hospital for Joint Diseases , New York, NY 10003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Ghersi","sequence":"additional","affiliation":[{"name":"Department of Oncology, Biology and Genetics, University of Genoa , Genoa ,","place":["Italy"]},{"name":"Department of Rheumatology, Hospital for Joint Diseases , New York, NY 10003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Puzone","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, National Institute for Cancer Research, University of Genoa , Genoa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Celada","sequence":"additional","affiliation":[{"name":"Department of Oncology, Biology and Genetics, University of Genoa , Genoa ,","place":["Italy"]},{"name":"Department of Rheumatology, Hospital for Joint Diseases , New York, NY 10003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liisa K","family":"Selin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical School , Worcester, MA 01655"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond M","family":"Welsh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical School , Worcester, MA 01655"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,4,1]]},"reference":[{"key":"2025032808045449800_R1","first-page":"5965","volume-title":"J. Virol.","year":"2001"},{"key":"2025032808045449800_R2","first-page":"655","volume-title":"J. Immunol.","year":"2003"},{"key":"2025032808045449800_R3","first-page":"1358","volume-title":"Br. Med. J.","year":"2003"},{"key":"2025032808045449800_R4","first-page":"339","volume-title":"Clin. Exp. Immunol.","year":"2002"},{"key":"2025032808045449800_R5","first-page":"397","volume-title":"J. Gen. Virol.","year":"1996"},{"key":"2025032808045449800_R6","first-page":"1311","volume-title":"J. Am. Vet. Med. Assoc.","year":"1991"},{"key":"2025032808045449800_R7","first-page":"10372","volume-title":"J. Virol.","year":"2001"},{"key":"2025032808045449800_R8","first-page":"4420","volume-title":"J. Virol.","year":"2002"},{"key":"2025032808045449800_R9","first-page":"4352","volume-title":"J. Immunol.","year":"2003"},{"key":"2025032808045449800_R10","first-page":"79","volume-title":"Am. J. Pathol.","year":"1995"},{"key":"2025032808045449800_R11","first-page":"1820","volume-title":"J. Immunol.","year":"2005"},{"key":"2025032808045449800_R12","first-page":"247","volume-title":"Immunity","year":"2005"},{"key":"2025032808045449800_R13","first-page":"2123","volume-title":"Eur. J. Immunol.","year":"2003"},{"key":"2025032808045449800_R14","first-page":"939","volume-title":"J. Immunol.","year":"1977"},{"key":"2025032808045449800_R15","first-page":"1567","volume-title":"Eur. J. Immunol.","year":"2002"},{"key":"2025032808045449800_R16","first-page":"3353","volume-title":"J. Immunol.","year":"2003"},{"key":"2025032808045449800_R17","first-page":"87","volume-title":"Immunity","year":"1995"},{"key":"2025032808045449800_R18","first-page":"59","volume-title":"Virology","year":"1976"},{"key":"2025032808045449800_R19","first-page":"1710","volume-title":"J. Immunol.","year":"1989"},{"key":"2025032808045449800_R20","first-page":"1918","volume-title":"Science","year":"1994"},{"key":"2025032808045449800_R21","first-page":"2452","volume-title":"Eur. J. Immunol.","year":"1994"},{"key":"2025032808045449800_R22","first-page":"321","volume-title":"Virology","year":"1988"},{"key":"2025032808045449800_R23","first-page":"158","volume-title":"Virology","year":"1998"},{"key":"2025032808045449800_R24","first-page":"627","volume-title":"Nat. Immunol.","year":"2002"},{"key":"2025032808045449800_R25","first-page":"685","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2025032808045449800_R26","first-page":"33","volume-title":"J. Immunol. Methods","year":"1997"},{"key":"2025032808045449800_R27","first-page":"3215","volume-title":"J. Immunol.","year":"1998"},{"key":"2025032808045449800_R28","first-page":"611","volume-title":"Frontiers of Life, Vol. II. Part 2","year":"2001"},{"key":"2025032808045449800_R29","first-page":"1350","volume-title":"Eur. J. Immunol.","year":"1996"},{"key":"2025032808045449800_R30","first-page":"56","volume-title":"Immunol. Today","year":"1992"},{"key":"2025032808045449800_R31","first-page":"862","volume-title":"Vaccine","year":"2000"},{"key":"2025032808045449800_R32","first-page":"329","volume-title":"J. Theor. Biol.","year":"1992"},{"key":"2025032808045449800_R33","first-page":"1251","volume-title":"Oncogene","year":"2002"},{"key":"2025032808045449800_R34","first-page":"481","volume-title":"Cell","year":"1998"},{"key":"2025032808045449800_R35","first-page":"491","volume-title":"Cell","year":"1998"},{"key":"2025032808045449800_R36","volume-title":"Macrophages directly prime naive CD8+ T cells","year":"2005"},{"key":"2025032808045449800_R37","first-page":"521","volume-title":"J. Exp. Med.","year":"1984"},{"key":"2025032808045449800_R38","first-page":"67","volume-title":"Nature","year":"1977"},{"key":"2025032808045449800_R39","first-page":"163","volume-title":"J. Exp. Med.","year":"1978"},{"key":"2025032808045449800_R40","first-page":"4911","volume-title":"J. Virol.","year":"2003"},{"key":"2025032808045449800_R41","first-page":"3139","volume-title":"J. Immunol.","year":"2004"},{"key":"2025032808045449800_R42","first-page":"2057","volume-title":"Science","year":"1997"},{"key":"2025032808045449800_R43","first-page":"284","volume-title":"Eur. J. Immunol.","year":"1999"},{"key":"2025032808045449800_R44","first-page":"47","volume-title":"Nat. Immunol.","year":"2000"},{"key":"2025032808045449800_R45","first-page":"3760","volume-title":"J. Immunol.","year":"2002"},{"key":"2025032808045449800_R46","first-page":"883","volume-title":"Genes Dev.","year":"2003"},{"key":"2025032808045449800_R47","first-page":"2976","volume-title":"J. Immunol.","year":"2004"},{"key":"2025032808045449800_R48","first-page":"395","volume-title":"Nature","year":"2002"},{"key":"2025032808045449800_R49","first-page":"1465","volume-title":"Science","year":"2005"},{"key":"2025032808045449800_R50","first-page":"560","volume-title":"Eur. J. Immunol.","year":"1998"},{"key":"2025032808045449800_R51","first-page":"107","volume-title":"Curr. Top. Microbiol. Immunol.","year":"2000"},{"key":"2025032808045449800_R52","first-page":"2335","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2025032808045449800_R53","first-page":"733","volume-title":"Immunity","year":"1999"},{"key":"2025032808045449800_R54","first-page":"2489","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2025032808045449800_R55","first-page":"7756","volume-title":"J. Virol.","year":"2003"},{"key":"2025032808045449800_R56","first-page":"1167","volume-title":"Mech. Ageing Dev.","year":"2002"},{"key":"2025032808045449800_R57","first-page":"1067","volume-title":"Nat. Immunol.","year":"2001"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/176\/7\/4284\/62635887\/4284.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/176\/7\/4284\/62635887\/4284.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T23:58:03Z","timestamp":1743379083000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/176\/7\/4284\/8034477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,1]]},"references-count":57,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,4,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.176.7.4284","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2006,4]]},"published":{"date-parts":[[2006,4,1]]}}}