{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:51:07Z","timestamp":1789977067174,"version":"4.0.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Molecular mimicry between Streptococcus pyogenes Ags and human proteins has been considered as a mechanism leading to autoimmune reactions in rheumatic fever and rheumatic heart disease (RHD). Cardiac myosin has been shown as a putative autoantigen recognized by autoantibodies of rheumatic fever patients. We assessed the human heart-intralesional T cell response against human light meromyosin (LMM) and streptococcal M5 peptides and mitral-valve-derived proteins by proliferation assay. Cytokines induced by LMM peptides were also evaluated. The frequency of intralesional T cell clones that recognized LMM peptides was 63.2%. Thirty-four percent of T cell clones presented cross-reactivity with different patterns: 1) myosin and valve-derived proteins; 2) myosin and streptococcal M5 peptides; and 3) myosin, valve-derived proteins and M5 peptides. In addition, several LMM peptides were recognized simultaneously showing a multiple reactivity pattern of heart-infiltrating T cells. Inflammatory cytokines (IFN-\u03b3 and TNF-\u03b1) were predominantly produced by heart-infiltrating T cells upon stimulation with LMM peptides. The alignment of LMM and streptococcal M5 peptides showed frequent homology among conserved amino acid substitutions. This is the first study showing the cellular response by human heart-infiltrating T cells against cardiac myosin epitopes in RHD patients. The high percentage of reactivity against cardiac myosin strengthens its role as one of the major autoantigens involved in rheumatic heart lesions. T cell reactivity toward myosin epitopes in RHD patients may also trigger the broad recognition of valvular proteins with structural or functional similarities.<\/jats:p>","DOI":"10.4049\/jimmunol.176.9.5662","type":"journal-article","created":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T21:31:36Z","timestamp":1398029496000},"page":"5662-5670","source":"Crossref","is-referenced-by-count":135,"title":["Mimicry in Recognition of Cardiac Myosin Peptides by Heart-Intralesional T Cell Clones from Rheumatic Heart Disease"],"prefix":"10.1093","volume":"176","author":[{"given":"Kellen C","family":"Fae\u0301","sequence":"first","affiliation":[{"name":"Heart Institute (Instituto do Corac\u0327a\u0303o) University of Sa\u0303o Paulo, School of Medicine , Sa\u0303o Paulo ,","place":["Brazil"]},{"name":"Institute for Immunology Investigation, Millenium Institute , Sa\u0303o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Diefenbach","family":"da Silva","sequence":"additional","affiliation":[{"name":"Heart Institute (Instituto do Corac\u0327a\u0303o) University of Sa\u0303o Paulo, School of Medicine , Sa\u0303o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra E","family":"Oshiro","sequence":"additional","affiliation":[{"name":"Heart Institute (Instituto do Corac\u0327a\u0303o) University of Sa\u0303o Paulo, School of Medicine , Sa\u0303o Paulo ,","place":["Brazil"]},{"name":"Institute for Immunology Investigation, Millenium Institute , Sa\u0303o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Heart Institute (Instituto do Corac\u0327a\u0303o) University of Sa\u0303o Paulo, School of Medicine , Sa\u0303o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo M A","family":"Pomerantzeff","sequence":"additional","affiliation":[{"name":"Heart Institute (Instituto do Corac\u0327a\u0303o) University of Sa\u0303o Paulo, School of Medicine , Sa\u0303o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Douay","sequence":"additional","affiliation":[{"name":"Assistance Publique-Ho\u0302pitaux de Paris, Centre d\u2019Investigations Biome\u0301dicales, Laboratoire d\u2019Immunologie et Histocompatibilite\u0301, Institut National de la Sante et de la Recherche Medicale Unite\u0301 662, Universite\u0301 Paris VII, Institut Universitaire d\u2019He\u0301matologie, Ho\u0302pital Saint Louis , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Charron","sequence":"additional","affiliation":[{"name":"Assistance Publique-Ho\u0302pitaux de Paris, Centre d\u2019Investigations Biome\u0301dicales, Laboratoire d\u2019Immunologie et Histocompatibilite\u0301, Institut National de la Sante et de la Recherche Medicale Unite\u0301 662, Universite\u0301 Paris VII, Institut Universitaire d\u2019He\u0301matologie, Ho\u0302pital Saint Louis , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Toubert","sequence":"additional","affiliation":[{"name":"Assistance Publique-Ho\u0302pitaux de Paris, Centre d\u2019Investigations Biome\u0301dicales, Laboratoire d\u2019Immunologie et Histocompatibilite\u0301, Institut National de la Sante et de la Recherche Medicale Unite\u0301 662, Universite\u0301 Paris VII, Institut Universitaire d\u2019He\u0301matologie, Ho\u0302pital Saint Louis , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine W","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center , Oklahoma City, OK, 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Kalil","sequence":"additional","affiliation":[{"name":"Heart Institute (Instituto do Corac\u0327a\u0303o) University of Sa\u0303o Paulo, School of Medicine , Sa\u0303o Paulo ,","place":["Brazil"]},{"name":"Institute for Immunology Investigation, Millenium Institute , Sa\u0303o Paulo ,","place":["Brazil"]},{"name":"Clinical Immunology and Allergy, Department of Clinical Medicine, University of Sa\u0303o Paulo, School of Medicine , Sa\u0303o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza","family":"Guilherme","sequence":"additional","affiliation":[{"name":"Heart Institute (Instituto do Corac\u0327a\u0303o) University of Sa\u0303o Paulo, School of Medicine , Sa\u0303o Paulo ,","place":["Brazil"]},{"name":"Institute for Immunology Investigation, Millenium Institute , Sa\u0303o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,5,1]]},"reference":[{"key":"2026020211371895600_R1","first-page":"272","volume-title":"Medicine","year":"1993"},{"key":"2026020211371895600_R2","first-page":"504","volume-title":"Rheumatic Fever","year":"1999"},{"key":"2026020211371895600_R3","first-page":"595","volume-title":"J. Immunol.","year":"1963"},{"key":"2026020211371895600_R4","first-page":"637","volume-title":"N. Engl. J. M.","year":"1964"},{"key":"2026020211371895600_R5","first-page":"459","volume-title":"Am. J. Cardiol.","year":"1969"},{"key":"2026020211371895600_R6","first-page":"470","volume-title":"Clin. Microbiol. Rev.","year":"2000"},{"key":"2026020211371895600_R7","first-page":"147","volume-title":"Adv. Immunol.","year":"1967"},{"key":"2026020211371895600_R8","first-page":"413","volume-title":"Science","year":"1985"},{"key":"2026020211371895600_R9","first-page":"2677","volume-title":"J. Immunol.","year":"1989"},{"key":"2026020211371895600_R10","first-page":"217","volume-title":"J. Clin. Invest.","year":"2000"},{"key":"2026020211371895600_R11","first-page":"5593","volume-title":"J. Immunol.","year":"1994"},{"key":"2026020211371895600_R12","first-page":"2101","volume-title":"Life Sci.","year":"2003"},{"key":"2026020211371895600_R13","first-page":"507","volume-title":"J. Infect. Dis.","year":"2001"},{"key":"2026020211371895600_R14","first-page":"90","volume-title":"Am. J. Med.","year":"1983"},{"key":"2026020211371895600_R15","first-page":"225","volume-title":"Clin. Immunol. Immunopathol.","year":"1989"},{"key":"2026020211371895600_R16","first-page":"415","volume-title":"Circulation","year":"1995"},{"key":"2026020211371895600_R17","first-page":"733","volume-title":"Streptococcal Diseases and the Immune Response","year":"1980"},{"key":"2026020211371895600_R18","first-page":"1825","volume-title":"J. Exp. Med.","year":"1987"},{"key":"2026020211371895600_R19","first-page":"4324","volume-title":"Infect. Immun.","year":"1991"},{"key":"2026020211371895600_R20","first-page":"1062","volume-title":"Infect. Immun.","year":"1993"},{"key":"2026020211371895600_R21","first-page":"3913","volume-title":"Infect. Immun.","year":"1997"},{"key":"2026020211371895600_R22","first-page":"4072","volume-title":"Infect. Immun.","year":"2001"},{"key":"2026020211371895600_R23","first-page":"297","volume-title":"Am. J. Pathol.","year":"2002"},{"key":"2026020211371895600_R24","first-page":"214","volume-title":"Hum. Genet.","year":"1989"},{"key":"2026020211371895600_R25","first-page":"5131","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1985"},{"key":"2026020211371895600_R26","first-page":"1064","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1985"},{"key":"2026020211371895600_R27","first-page":"4689","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1981"},{"key":"2026020211371895600_R28","first-page":"4007","volume-title":"J. Biol. Chem.","year":"1975"},{"key":"2026020211371895600_R29","first-page":"5","volume-title":"J. Immunol. Methods","year":"1987"},{"key":"2026020211371895600_R30","first-page":"176","volume-title":"Immunol. Today","year":"1995"},{"key":"2026020211371895600_R31","first-page":"2141","volume-title":"J. Immunol.","year":"1991"},{"key":"2026020211371895600_R32","first-page":"285","volume-title":"Am. J. Pathol.","year":"1991"},{"key":"2026020211371895600_R33","first-page":"5448","volume-title":"J. Immunol.","year":"2005"},{"key":"2026020211371895600_R34","first-page":"155","volume-title":"Nature","year":"1992"},{"key":"2026020211371895600_R35","first-page":"901","volume-title":"Mol. Immunol.","year":"2000"},{"key":"2026020211371895600_R36","first-page":"5345","volume-title":"Infect. Immun.","year":"2001"},{"key":"2026020211371895600_R37","first-page":"395","volume-title":"Immunol. Today","year":"1998"},{"key":"2026020211371895600_R38","first-page":"337","volume-title":"J. Autoimmun.","year":"2001"},{"key":"2026020211371895600_R39","first-page":"1129","volume-title":"Mol. Immunol.","year":"2004"},{"key":"2026020211371895600_R40","first-page":"1063","volume-title":"Int. Immunol.","year":"2000"},{"key":"2026020211371895600_R41","first-page":"1094","volume-title":"J. Immunol.","year":"1998"},{"key":"2026020211371895600_R42","first-page":"194","volume-title":"Immunology","year":"2004"},{"key":"2026020211371895600_R43","first-page":"1583","volume-title":"Am. J. Pathol.","year":"2004"},{"key":"2026020211371895600_R44","first-page":"695","volume-title":"Cell","year":"1995"},{"key":"2026020211371895600_R45","first-page":"1597","volume-title":"J. Exp. Med.","year":"1995"},{"key":"2026020211371895600_R46","first-page":"171","volume-title":"Curr. Dir. Autoimmun.","year":"2001"},{"key":"2026020211371895600_R47","first-page":"908","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020211371895600_R48","first-page":"1121","volume-title":"Mol. Immunol.","year":"2004"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/176\/9\/5662\/62635344\/5662.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/176\/9\/5662\/62635344\/5662.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T16:37:34Z","timestamp":1770050254000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/176\/9\/5662\/8034450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,1]]},"references-count":48,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2006,5,1]]},"published-print":{"date-parts":[[2006,5,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.176.9.5662","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2006,5]]},"published":{"date-parts":[[2006,5,1]]}}}