{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:51:05Z","timestamp":1790049065873,"version":"4.0.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>T-bet and STAT1 regulate IFN-\u03b3 gene transcription in CD4+ T cells, which mediate protection against Leishmania. Here we show that T-bet and STAT1 are required for the induction of an efficient Th1 response during Leishmania donovani infection, but they play distinct roles in determining disease outcome. Both STAT1\u2212\/\u2212 and T-bet\u2212\/\u2212 mice failed to mount a Th1 response, but STAT1\u2212\/\u2212 mice were highly resistant to L. donovani and developed less immunopathology, whereas T-bet\u2212\/\u2212 mice were highly susceptible and eventually developed liver inflammation. Adoptive cell transfer studies showed that RAG2\u2212\/\u2212 recipients receiving STAT1+\/+ or STAT1\u2212\/\u2212 T cells developed comparable liver pathology, but those receiving STAT1\u2212\/\u2212 T cells were significantly more susceptible to infection. These unexpected findings reveal distinct roles for T-bet and STAT1 in mediating host immunity and liver pathology during visceral leishmaniasis.<\/jats:p>","DOI":"10.4049\/jimmunol.177.1.22","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:47:14Z","timestamp":1397850434000},"page":"22-25","source":"Crossref","is-referenced-by-count":46,"title":["Cutting Edge: STAT1 and T-bet Play Distinct Roles in Determining Outcome of Visceral Leishmaniasis Caused by\n                    <i>Leishmania donovani<\/i>"],"prefix":"10.1093","volume":"177","author":[{"given":"Lucia E","family":"Rosas","sequence":"first","affiliation":[{"name":"Department of Microbiology, Ohio State University , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi M","family":"Snider","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ohio State University , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Barbi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ohio State University , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali A","family":"Satoskar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ohio State University , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geanncarlo","family":"Lugo-Villarino","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard School of Public Health , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Keiser","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ohio State University , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Papenfuss","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan E","family":"Durbin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital , Columbus, OH 43205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danuta","family":"Radzioch","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Human Genetics, Montreal General Hospital , Montreal ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie H","family":"Glimcher","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard School of Public Health , Boston, MA 02115"},{"name":"Department of Medicine, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay R","family":"Satoskar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ohio State University , Columbus, OH 43210"},{"name":"Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University , Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,7,1]]},"reference":[{"key":"2026020210152132200_R1","first-page":"2993","volume-title":"J. 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