{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:39:27Z","timestamp":1790404767676,"version":"4.1.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CXCL13\/CXCR5 and CCL19\/CCR7 play a quite important role in normal physiological conditions, but the functions of both chemokine\/receptor pairs in pathophysiological events are not well-investigated. We have investigated expression and functions of CXCL13\/CXCR5 and CCL19\/CCR7 in CD23+CD5+ and CD23+CD5\u2212 B cells from cord blood (CB) and patients with B cell lineage acute or chronic lymphocytic leukemia (B-ALL or B-CLL). CXCR5 and CCR7 are selectively expressed on B-ALL, B-CLL, and CB CD23+CD5+ B cells at high frequency, but not on CD23+CD5\u2212 B cells. Although no significant chemotactic responsiveness was observed, CXCL13 and CCL19 cooperatively induce significant resistance to TNF-\u03b1-mediated apoptosis in B-ALL and B-CLL CD23+CD5+ B cells, but not in the cells from CB. B-ALL and B-CLL CD23+CD5+ B cells express elevated levels of paternally expressed gene 10 (PEG10). CXCL13 and CCL19 together significantly up-regulate PEG10 expression in the same cells. We have found that CXCL13 and CCL19 together by means of activation of CXCR5 and CCR7 up-regulate PEG10 expression and function, subsequently stabilize caspase-3 and caspase-8 in B-ALL and B-CLL CD23+CD5+ B cells, and further rescue the cells from TNF-\u03b1-mediated apoptosis. Therefore, we suggest that normal lymphocytes, especially naive B and T cells, use CXCL13\/CXCR5 and CCL19\/CCR7 for migration, homing, maturation, and cell homeostasis as well as secondary lymphoid tissues organogenesis. In addition, certain malignant cells take advantages of CXCL13\/CXCR5 and CCL19\/CCR7 for infiltration, resistance to apoptosis, and inappropriate proliferation.<\/jats:p>","DOI":"10.4049\/jimmunol.177.10.6713","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:39:04Z","timestamp":1397864344000},"page":"6713-6722","source":"Crossref","is-referenced-by-count":58,"title":["CXC Chemokine Ligand 13 and CC Chemokine Ligand 19 Cooperatively Render Resistance to Apoptosis in B Cell Lineage Acute and Chronic Lymphocytic Leukemia CD23+CD5+ B Cells"],"prefix":"10.1093","volume":"177","author":[{"given":"Hu","family":"Chunsong","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Basic Medical Sciences, Anhui Medical University , Hefei ,","place":["China"]},{"name":"Department of Immunology, and Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-Related Diseases and Center for Medical Research, Wuhan University School of Medicine , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Yuling","sequence":"additional","affiliation":[{"name":"Department of Immunology, and Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-Related Diseases and Center for Medical Research, Wuhan University School of Medicine , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Immunology, and Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-Related Diseases and Center for Medical Research, Wuhan University School of Medicine , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Jie","sequence":"additional","affiliation":[{"name":"Department of Immunology, and Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-Related Diseases and Center for Medical Research, Wuhan University School of Medicine , Wuhan ,","place":["China"]},{"name":"The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Gang","sequence":"additional","affiliation":[{"name":"Department of Immunology, and Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-Related Diseases and Center for Medical Research, Wuhan University School of Medicine , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Qiuping","sequence":"additional","affiliation":[{"name":"Department of Immunology, and Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-Related Diseases and Center for Medical Research, Wuhan University School of Medicine , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao","family":"Qingping","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Renmin and Zongnan University Hospital, Wuhan University , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Kejian","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Renmin and Zongnan University Hospital, Wuhan University , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Immunology, and Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-Related Diseases and Center for Medical Research, Wuhan University School of Medicine , Wuhan ,","place":["China"]},{"name":"Department of Surgery, University of Michigan Medical Center , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred E","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Michigan Medical Center , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Youxin","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tan","family":"Jinquan","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Basic Medical Sciences, Anhui Medical University , Hefei ,","place":["China"]},{"name":"Department of Immunology, and Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-Related Diseases and Center for Medical Research, Wuhan University School of Medicine , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,11,15]]},"reference":[{"key":"2025032704311320500_R1","first-page":"2035","volume-title":"Eur. J. Immunol.","year":"1996"},{"key":"2025032704311320500_R2","first-page":"117","volume-title":"Immunol. Rev.","year":"2003"},{"key":"2025032704311320500_R3","first-page":"5096","volume-title":"J. Immunol.","year":"2002"},{"key":"2025032704311320500_R4","first-page":"830","volume-title":"Blood","year":"1994"},{"key":"2025032704311320500_R5","first-page":"2808","volume-title":"Eur. J. Immunol.","year":"2000"},{"key":"2025032704311320500_R6","first-page":"5117","volume-title":"J. Immunol.","year":"2002"},{"key":"2025032704311320500_R7","first-page":"309","volume-title":"Nature","year":"2000"},{"key":"2025032704311320500_R8","first-page":"799","volume-title":"Nature","year":"1998"},{"key":"2025032704311320500_R9","first-page":"1037","volume-title":"Cell","year":"1996"},{"key":"2025032704311320500_R10","first-page":"65","volume-title":"J. Exp. Med.","year":"2002"},{"key":"2025032704311320500_R11","first-page":"94","volume-title":"Nature","year":"2002"},{"key":"2025032704311320500_R12","first-page":"708","volume-title":"Nature","year":"1999"},{"key":"2025032704311320500_R13","first-page":"3096","volume-title":"J. Immunol.","year":"1998"},{"key":"2025032704311320500_R14","first-page":"258","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1998"},{"key":"2025032704311320500_R15","first-page":"1199","volume-title":"J. Exp. Med.","year":"2003"},{"key":"2025032704311320500_R16","first-page":"471","volume-title":"Immunity","year":"2000"},{"key":"2025032704311320500_R17","first-page":"363","volume-title":"Immunity","year":"2002"},{"key":"2025032704311320500_R18","first-page":"815","volume-title":"Blood","year":"2003"},{"key":"2025032704311320500_R19","first-page":"R49","volume-title":"J. Clin. Invest.","year":"1999"},{"key":"2025032704311320500_R20","first-page":"232","volume-title":"Genomics","year":"2001"},{"key":"2025032704311320500_R21","first-page":"101","volume-title":"Nat. Genet.","year":"2006"},{"key":"2025032704311320500_R22","first-page":"3043","volume-title":"Cancer Res.","year":"2003"},{"key":"2025032704311320500_R23","first-page":"665","volume-title":"Cancer Res.","year":"2006"},{"key":"2025032704311320500_R24","first-page":"553","volume-title":"Br. J. Haematol.","year":"1981"},{"key":"2025032704311320500_R25","first-page":"4990","volume-title":"Blood","year":"1996"},{"key":"2025032704311320500_R26","first-page":"567","volume-title":"J. Clin. Pathol.","year":"1989"},{"key":"2025032704311320500_R27","first-page":"6469","volume-title":"Cancer Res.","year":"2003"},{"key":"2025032704311320500_R28","first-page":"1230","volume-title":"Blood","year":"2000"},{"key":"2025032704311320500_R29","first-page":"1722","volume-title":"J. Immunol.","year":"2003"},{"key":"2025032704311320500_R30","first-page":"195","volume-title":"J. Immunol. Methods","year":"1997"},{"key":"2025032704311320500_R31","first-page":"969","volume-title":"J. Exp. Med.","year":"1997"},{"key":"2025032704311320500_R32","first-page":"9070","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2000"},{"key":"2025032704311320500_R33","first-page":"925","volume-title":"Blood","year":"2001"},{"key":"2025032704311320500_R34","first-page":"700","volume-title":"Nucleic Acids Res.","year":"2003"},{"key":"2025032704311320500_R35","first-page":"264","volume-title":"Virology","year":"1999"},{"key":"2025032704311320500_R36","first-page":"150","volume-title":"Immunol. Rev.","year":"2000"},{"key":"2025032704311320500_R37","first-page":"1911","volume-title":"Blood","year":"2000"},{"key":"2025032704311320500_R38","first-page":"1611","volume-title":"J. Immunol.","year":"1999"},{"key":"2025032704311320500_R39","first-page":"2505","volume-title":"Blood","year":"2000"},{"key":"2025032704311320500_R40","first-page":"1312","volume-title":"Science","year":"1998"},{"key":"2025032704311320500_R41","first-page":"50","volume-title":"Nature","year":"2001"},{"key":"2025032704311320500_R42","first-page":"4747","volume-title":"J. Immunol.","year":"2001"},{"key":"2025032704311320500_R43","first-page":"4961","volume-title":"Cancer Res.","year":"2001"},{"key":"2025032704311320500_R44","first-page":"752","volume-title":"Leukemia","year":"2001"},{"key":"2025032704311320500_R45","first-page":"3658","volume-title":"Blood","year":"1999"},{"key":"2025032704311320500_R46","first-page":"2977","volume-title":"Blood","year":"2002"},{"key":"2025032704311320500_R47","first-page":"1109","volume-title":"Blood","year":"2002"},{"key":"2025032704311320500_R48","first-page":"271","volume-title":"Apoptosis","year":"2002"},{"key":"2025032704311320500_R49","first-page":"2328","volume-title":"Blood","year":"1997"},{"key":"2025032704311320500_R50","first-page":"1158","volume-title":"Blood","year":"2000"},{"key":"2025032704311320500_R51","first-page":"12556","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1998"},{"key":"2025032704311320500_R52","first-page":"1467","volume-title":"AIDS","year":"2002"},{"key":"2025032704311320500_R53","first-page":"1743","volume-title":"Hum. Mol. Genet.","year":"2002"},{"key":"2025032704311320500_R54","first-page":"1696","volume-title":"Genome Res.","year":"2003"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/177\/10\/6713\/62648334\/zim02206006713.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/177\/10\/6713\/62648334\/zim02206006713.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T05:24:06Z","timestamp":1743312246000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/177\/10\/6713\/8059483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":54,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,11,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.177.10.6713","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2006,11]]},"published":{"date-parts":[[2006,11]]}}}