{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:13:33Z","timestamp":1791296013704,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Allergic airway diseases such as asthma are caused by a failure of the immune system to induce tolerance against environmental Ags. The underlying molecular and cellular mechanisms that initiate tolerance are only partly understood. In this study, we demonstrated that a CCR7-dependent migration of both CD103+ and CD103\u2212 lung dendritic cells (DC) to the bronchial lymph node (brLN) is indispensable for this process. Although inhaled Ag is amply present in the brLN of CCR7-deficient mice, T cells cannot be tolerized because of the impaired migration of Ag-carrying DC and subsequent transport of Ag from the lung to the draining lymph node. Consequently, the repeated inhalation of Ag protects wild-type but not CCR7-deficient mice from developing allergic airway diseases. Thus, the continuous DC-mediated transport of inhaled Ag to the brLN is critical for the induction of tolerance to innocuous Ags.<\/jats:p>","DOI":"10.4049\/jimmunol.177.10.7346","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:39:04Z","timestamp":1397849944000},"page":"7346-7354","source":"Crossref","is-referenced-by-count":183,"title":["Induction of Tolerance to Innocuous Inhaled Antigen Relies on a CCR7-Dependent Dendritic Cell-Mediated Antigen Transport to the Bronchial Lymph Node"],"prefix":"10.1093","volume":"177","author":[{"given":"Gabriele","family":"Hintzen","sequence":"first","affiliation":[{"name":"Institute of Immunology, Hannover Medical School , Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Ohl","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School , Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Luisa","family":"del Rio","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School , Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose-Ignacio","family":"Rodriguez-Barbosa","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School , Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Pabst","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School , Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R","family":"Kocks","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School , Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Krege","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School , Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja","family":"Hardtke","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School , Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhold","family":"Fo\u0308rster","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Hannover Medical School , Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,11,15]]},"reference":[{"key":"2026020214063454100_R1","first-page":"271","volume-title":"Annu. Rev. Immunol.","year":"1991"},{"key":"2026020214063454100_R2","first-page":"597","volume-title":"Clin. Exp. Allergy","year":"1989"},{"key":"2026020214063454100_R3","first-page":"769","volume-title":"J. Exp. Med.","year":"2001"},{"key":"2026020214063454100_R4","first-page":"1627","volume-title":"J. Exp. Med.","year":"2002"},{"key":"2026020214063454100_R5","first-page":"279","volume-title":"Immunity","year":"2004"},{"key":"2026020214063454100_R6","first-page":"445","volume-title":"Trends Immunol.","year":"2002"},{"key":"2026020214063454100_R7","first-page":"239","volume-title":"J. Exp. Med.","year":"1997"},{"key":"2026020214063454100_R8","first-page":"217","volume-title":"J. Exp. Med.","year":"2002"},{"key":"2026020214063454100_R9","first-page":"228","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020214063454100_R10","first-page":"551","volume-title":"J. Exp. Med.","year":"2001"},{"key":"2026020214063454100_R11","first-page":"265","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2026020214063454100_R12","first-page":"1353","volume-title":"Am. J. Pathol.","year":"2002"},{"key":"2026020214063454100_R13","first-page":"994","volume-title":"Nat. Rev. Immunol.","year":"2003"},{"key":"2026020214063454100_R14","first-page":"1524","volume-title":"J. Immunol.","year":"2002"},{"key":"2026020214063454100_R15","first-page":"23","volume-title":"Cell","year":"1999"},{"key":"2026020214063454100_R16","first-page":"451","volume-title":"J. Exp. Med.","year":"1999"},{"key":"2026020214063454100_R17","first-page":"830","volume-title":"Blood","year":"1994"},{"key":"2026020214063454100_R18","first-page":"1199","volume-title":"J. Exp. Med.","year":"2003"},{"key":"2026020214063454100_R19","first-page":"472","volume-title":"J. Leukocyte Biol.","year":"2004"},{"key":"2026020214063454100_R20","first-page":"98","volume-title":"Eur. J. Immunol.","year":"2005"},{"key":"2026020214063454100_R21","first-page":"111","volume-title":"J. Immunol. Methods","year":"2004"},{"key":"2026020214063454100_R22","first-page":"3578","volume-title":"J. Immunol.","year":"2006"},{"key":"2026020214063454100_R23","first-page":"341","volume-title":"Immunity","year":"2004"},{"key":"2026020214063454100_R24","first-page":"19","volume-title":"Immunity","year":"2005"},{"key":"2026020214063454100_R25","first-page":"8670","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2004"},{"key":"2026020214063454100_R26","first-page":"845","volume-title":"Nature","year":"2002"},{"key":"2026020214063454100_R27","first-page":"524","volume-title":"Nat. Immunol.","year":"2004"},{"key":"2026020214063454100_R28","first-page":"958","volume-title":"Science","year":"1999"},{"key":"2026020214063454100_R29","first-page":"657","volume-title":"J. Exp. Med.","year":"2002"},{"key":"2026020214063454100_R30","first-page":"1662","volume-title":"Science","year":"2004"},{"key":"2026020214063454100_R31","first-page":"519","volume-title":"J. Exp. Med.","year":"2006"},{"key":"2026020214063454100_R32","first-page":"47","volume-title":"Immunity","year":"2003"},{"key":"2026020214063454100_R33","first-page":"125","volume-title":"Immunol. Rev.","year":"2003"},{"key":"2026020214063454100_R34","first-page":"725","volume-title":"Nat. Immunol.","year":"2001"},{"key":"2026020214063454100_R35","first-page":"1063","volume-title":"J. Exp. Med.","year":"2005"},{"key":"2026020214063454100_R36","first-page":"1051","volume-title":"J. Exp. Med.","year":"2005"},{"key":"2026020214063454100_R37","first-page":"1020","volume-title":"N. Engl. J. Med.","year":"2000"},{"key":"2026020214063454100_R38","first-page":"2760","volume-title":"Eur. J. Immunol.","year":"1998"},{"key":"2026020214063454100_R39","first-page":"373","volume-title":"J. Exp. Med.","year":"1998"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/177\/10\/7346\/62646930\/zim02206007346.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/177\/10\/7346\/62646930\/zim02206007346.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:10:05Z","timestamp":1770059405000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/177\/10\/7346\/8059455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":39,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2006,11,15]]},"published-print":{"date-parts":[[2006,11,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.177.10.7346","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2006,11]]},"published":{"date-parts":[[2006,11]]}}}