{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:47:38Z","timestamp":1793839658741,"version":"4.6.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The fatty acid-binding protein (FABP) family consists of a number of conserved cytoplasmic proteins with roles in intracellular lipid transport, storage, and metabolism. Examination of a comprehensive leukocyte gene expression database revealed strong expression of the adipocyte FABP aP2 in human monocyte-derived dendritic cells (DCs). We isolated bone marrow-derived DC from aP2-deficient mice, and showed that expression of DC cytokines including IL-12 and TNF was significantly impaired in these cells. Degradation of I\u03baB\u03b1 was also impaired in aP2-deficient DCs, indicative of reduced signaling through the I\u03baB kinase-NF-\u03baB pathway. The cytokine defect was selective because there was no effect on Ag uptake or expression of MHC class II, CD40, CD80, or CD86. In an MLR, aP2-deficient DCs stimulated markedly lower T cell proliferation and cytokine production than did wild-type DCs. Moreover, aP2-deficient mice immunized with keyhole limpet hemocyanin\/CFA showed reduced production of IFN-\u03b3 by restimulated draining lymph node cells, suggesting a similar defect in DC function in vivo. Similarly, infection of aP2-deficient mice with the natural mouse pathogen ectromelia virus resulted in substantially lower production of IFN-\u03b3 by CD8+ T cells. Thus, FABP aP2 plays an important role in DC function and T cell priming, and provides an additional link between metabolic processes and the regulation of immune responses.<\/jats:p>","DOI":"10.4049\/jimmunol.177.11.7794","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T13:14:46Z","timestamp":1397826886000},"page":"7794-7801","source":"Crossref","is-referenced-by-count":85,"title":["Regulation of Dendritic Cell Function and T Cell Priming by the Fatty Acid-Binding Protein aP2"],"prefix":"10.1093","volume":"177","author":[{"given":"Michael S","family":"Rolph","sequence":"first","affiliation":[{"name":"Immunology and Inflammation Research Program, Garvan Institute for Medical Research, Darlinghurst , New South Wales ,","place":["Australia"]},{"name":"Cooperative Research Centre for Asthma , Camperdown, New South Wales ,","place":["Australia"]},{"name":"St. Vincent\u2019s Clinical School, Faculty of Medicine, University of New South Wales , Sydney ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R","family":"Young","sequence":"additional","affiliation":[{"name":"Immunology and Inflammation Research Program, Garvan Institute for Medical Research, Darlinghurst , New South Wales ,","place":["Australia"]},{"name":"Cooperative Research Centre for Asthma , Camperdown, New South Wales ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bennett O V","family":"Shum","sequence":"additional","affiliation":[{"name":"Immunology and Inflammation Research Program, Garvan Institute for Medical Research, Darlinghurst , New South Wales ,","place":["Australia"]},{"name":"Cooperative Research Centre for Asthma , Camperdown, New South Wales ,","place":["Australia"]},{"name":"St. Vincent\u2019s Clinical School, Faculty of Medicine, University of New South Wales , Sydney ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cem Z","family":"Gorgun","sequence":"additional","affiliation":[{"name":"Department of Genetics and Complex Diseases, Harvard School of Public Health , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Schmitz-Peiffer","sequence":"additional","affiliation":[{"name":"Diabetes and Obesity Research Program, Garvan Institute for Medical Research , Darlinghurst, New South Wales ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian A","family":"Ramshaw","sequence":"additional","affiliation":[{"name":"Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University , Canberra ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go\u0308khan S","family":"Hotamisligil","sequence":"additional","affiliation":[{"name":"Department of Genetics and Complex Diseases, Harvard School of Public Health , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R","family":"Mackay","sequence":"additional","affiliation":[{"name":"Immunology and Inflammation Research Program, Garvan Institute for Medical Research, Darlinghurst , New South Wales ,","place":["Australia"]},{"name":"Cooperative Research Centre for Asthma , Camperdown, New South Wales ,","place":["Australia"]},{"name":"St. Vincent\u2019s Clinical School, Faculty of Medicine, University of New South Wales , Sydney ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,12,1]]},"reference":[{"key":"2026012810565641900_R1","first-page":"767","volume-title":"Annu. Rev. Immunol.","year":"2000"},{"key":"2026012810565641900_R2","first-page":"255","volume-title":"Cell","year":"2001"},{"key":"2026012810565641900_R3","first-page":"263","volume-title":"Cell","year":"2001"},{"key":"2026012810565641900_R4","first-page":"203","volume-title":"J. Exp. Med.","year":"2005"},{"key":"2026012810565641900_R5","first-page":"759","volume-title":"Curr. Mol. Med.","year":"2003"},{"key":"2026012810565641900_R6","first-page":"328","volume-title":"Prog. Lipid Res.","year":"2004"},{"key":"2026012810565641900_R7","first-page":"175","volume-title":"Trends Endocrinol. Metab.","year":"2000"},{"key":"2026012810565641900_R8","first-page":"2464S","volume-title":"J. Nutr.","year":"2004"},{"key":"2026012810565641900_R9","first-page":"2042","volume-title":"Int. J. Biochem. Cell Biol.","year":"2004"},{"key":"2026012810565641900_R10","first-page":"699","volume-title":"Nat. Med.","year":"2001"},{"key":"2026012810565641900_R11","first-page":"2017","volume-title":"J. Lipid Res.","year":"2000"},{"key":"2026012810565641900_R12","first-page":"259","volume-title":"Atherosclerosis","year":"2002"},{"key":"2026012810565641900_R13","first-page":"12888","volume-title":"J. Biol. Chem.","year":"2005"},{"key":"2026012810565641900_R14","first-page":"7837","volume-title":"J. Immunol.","year":"2005"},{"key":"2026012810565641900_R15","first-page":"274","volume-title":"Nat. Immunol.","year":"2006"},{"key":"2026012810565641900_R16","first-page":"496","volume-title":"J. Allergy Clin. Immunol.","year":"2006"},{"key":"2026012810565641900_R17","first-page":"284","volume-title":"Pharmacol. Ther.","year":"2006"},{"key":"2026012810565641900_R18","first-page":"95","volume-title":"Immunity","year":"2004"},{"key":"2026012810565641900_R19","first-page":"2175","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2026012810565641900_R20","first-page":"1039","volume-title":"Blood","year":"2000"},{"key":"2026012810565641900_R21","first-page":"3888","volume-title":"Blood","year":"2005"},{"key":"2026012810565641900_R22","first-page":"1377","volume-title":"Science","year":"1996"},{"key":"2026012810565641900_R23","first-page":"77","volume-title":"J. Immunol. Methods","year":"1999"},{"key":"2026012810565641900_R24","first-page":"2183","volume-title":"J. Clin. Invest.","year":"2006"},{"key":"2026012810565641900_R25","first-page":"807","volume-title":"J. Immunol.","year":"2004"},{"key":"2026012810565641900_R26","first-page":"95","volume-title":"J. Exp. Med.","year":"2005"},{"key":"2026012810565641900_R27","first-page":"543","volume-title":"Curr. Opin. Lipidol.","year":"2005"},{"key":"2026012810565641900_R28","first-page":"107","volume-title":"Cell Metab.","year":"2005"},{"key":"2026012810565641900_R29","first-page":"1987","volume-title":"Diabetes","year":"1999"},{"key":"2026012810565641900_R30","first-page":"389","volume-title":"J. Exp. Med.","year":"1995"},{"key":"2026012810565641900_R31","first-page":"257","volume-title":"Immunity","year":"2002"},{"key":"2026012810565641900_R32","first-page":"2195","volume-title":"Genes Dev.","year":"2004"},{"key":"2026012810565641900_R33","first-page":"691","volume-title":"J. Immunol.","year":"2003"},{"key":"2026012810565641900_R34","first-page":"119","volume-title":"Immunol. Rev.","year":"1997"},{"key":"2026012810565641900_R35","first-page":"157","volume-title":"Mol. Cell. Biochem.","year":"2002"},{"key":"2026012810565641900_R36","first-page":"2323","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2001"},{"key":"2026012810565641900_R37","first-page":"5114","volume-title":"Mol. Cell. Biol.","year":"2002"},{"key":"2026012810565641900_R38","first-page":"71","volume-title":"J. Am. Coll. Nutr.","year":"2004"},{"key":"2026012810565641900_R39","first-page":"103","volume-title":"Nature","year":"2000"},{"key":"2026012810565641900_R40","first-page":"2423","volume-title":"FASEB J.","year":"2001"},{"key":"2026012810565641900_R41","first-page":"17920","volume-title":"J. Biol. Chem.","year":"2001"},{"key":"2026012810565641900_R42","first-page":"11520","volume-title":"Biochemistry","year":"2003"},{"key":"2026012810565641900_R43","first-page":"3388","volume-title":"Endocrinology","year":"2000"},{"key":"2026012810565641900_R44","first-page":"459","volume-title":"Biochem. Biophys. Res. Commun.","year":"2006"},{"key":"2026012810565641900_R45","first-page":"1685","volume-title":"N. Engl. J. Med.","year":"2005"},{"key":"2026012810565641900_R46","first-page":"1111","volume-title":"J. Clin. Invest.","year":"2005"},{"key":"2026012810565641900_R47","first-page":"423","volume-title":"Biochem. Soc. Trans.","year":"2005"},{"key":"2026012810565641900_R48","first-page":"43","volume-title":"Curr. Opin. Lipidol.","year":"2004"},{"key":"2026012810565641900_R49","first-page":"155","volume-title":"Curr. Opin. Lipidol.","year":"2002"},{"key":"2026012810565641900_R50","first-page":"1751","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2003"},{"key":"2026012810565641900_R51","first-page":"5390","volume-title":"J. Immunol.","year":"2005"},{"key":"2026012810565641900_R52","first-page":"33","volume-title":"Mol. Cell. Biochem.","year":"1999"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/177\/11\/7794\/62649632\/zim02306007794.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/177\/11\/7794\/62649632\/zim02306007794.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T15:57:49Z","timestamp":1769615869000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/177\/11\/7794\/8031779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,1]]},"references-count":52,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2006,12,1]]},"published-print":{"date-parts":[[2006,12,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.177.11.7794","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2006,12]]},"published":{"date-parts":[[2006,12,1]]}}}