{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:32:29Z","timestamp":1790908349491,"version":"4.1.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Helicobacter pylori infection is associated with the local production of chemokines and cytokines, of which IL-6 is overexpressed at the margin of gastric ulcer in H. pylori-positive gastritis. Cells of the monocytic lineage are the major sources of IL-6, and mononuclear cell infiltration in the lamina propria is characteristic of H. pylori-induced chronic infection. Our study shows for the first time that a secreted peptidyl prolyl cis-, trans-isomerase, HP0175 elicits IL-6 gene expression and IL-6 release from macrophages. An isogenic strain inactivated in the HP0175 gene (knockout) was attenuated in its IL-6-inducing ability, which was restored after complementation with the HP0175 gene. The specificity of the HP0175-induced effect was confirmed by the fact that rHP0175 purified from HEK293 cells could also induce IL-6 release, ruling out the possibility that the observed effect was due to bacterial contaminants. HP0175 was capable of interacting directly with the extracellular domain of TLR4. HP0175-induced IL-6 gene expression was critically dependent on TLR4-dependent NF-\u03baB and MAPK activation. TLR4\/PI3K-dependent ERK1\/2 and p38 MAPK signaling converged upon activation of mitogen- and stress-activated protein kinase 1 (MSK1). The central role of MSK1 was borne out by the fact that silencing of MSK1 expression abrogated HP0175-mediated NF-\u03baB-dependent IL-6 gene transcription. MSK1 regulated the recruitment of p65 and phopho-Ser10-histone H3 to the IL-6 promoter. HP0175 therefore regulated IL-6 gene transcription through chromatin modification at the IL-6 promoter.<\/jats:p>","DOI":"10.4049\/jimmunol.177.11.7950","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T13:14:46Z","timestamp":1397826886000},"page":"7950-7958","source":"Crossref","is-referenced-by-count":83,"title":["TLR4-Dependent NF-\u03baB Activation and Mitogen- and Stress-Activated Protein Kinase 1-Triggered Phosphorylation Events Are Central to\n                    <i>Helicobacter pylori<\/i>\n                    Peptidyl Prolyl\n                    <i>cis<\/i>\n                    -,\n                    <i>trans<\/i>\n                    -Isomerase (HP0175)-Mediated Induction of IL-6 Release from Macrophages"],"prefix":"10.1093","volume":"177","author":[{"given":"Sushil Kumar","family":"Pathak","sequence":"first","affiliation":[{"name":"Department of Chemistry, Bose Institute , Kolkata ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanchita","family":"Basu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Bose Institute , Kolkata ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asima","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Bose Institute , Kolkata ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shresh","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Bose Institute , Kolkata ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirban","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Bose Institute , Kolkata ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyoti","family":"Basu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Bose Institute , Kolkata ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manikuntala","family":"Kundu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Bose Institute , Kolkata ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,12,1]]},"reference":[{"key":"2026012810560645300_R1","first-page":"1175","volume-title":"N. 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