{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:10:17Z","timestamp":1779315017990,"version":"3.51.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The heat shock response is a canonical regulatory pathway by which cellular stressors such as heat and oxidative stress alter the expression of stress-responsive genes. Some of these stress-responsive genes (heat shock proteins and MHC class I (MHC I)-related chains) play a significant role in the immune system. In this study, we have investigated the impact of stimulating the heat shock response on genes involved in the MHC I presentation pathway. We report that two inducible subunits of the proteasome, lmp2 and lmp7, are transcriptionally up-regulated by heat shock in cells of mouse and human origin. Furthermore, heat-shocked cells show enhanced presentation of the immunoproteasome-dependent MHC I antigenic epitopes NP118\u2013126 of lymphocytic choriomeningitis virus and E1B192\u2013200 of adenovirus, but not immunoproteasome-independent epitopes such as tumor Ag AH1 and SV40 large T Ag epitope II223\u2013231. These findings show a novel immunological sequel to the cellular response to stress that may play a key role during fever or other homeostatic perturbations.<\/jats:p>","DOI":"10.4049\/jimmunol.177.12.8393","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T18:56:18Z","timestamp":1397847378000},"page":"8393-8399","source":"Crossref","is-referenced-by-count":31,"title":["Heat Shock Up-Regulates lmp2 and lmp7 and Enhances Presentation of Immunoproteasome-Dependent Epitopes"],"prefix":"10.1093","volume":"177","author":[{"given":"Margaret K","family":"Callahan","sequence":"first","affiliation":[{"name":"Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine , Farmington, CT 06030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A","family":"Wohlfert","sequence":"additional","affiliation":[{"name":"Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine , Farmington, CT 06030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Me\u0301noret","sequence":"additional","affiliation":[{"name":"Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine , Farmington, CT 06030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramod K","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine , Farmington, CT 06030"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,12,15]]},"reference":[{"key":"2026012810562465100_R1","first-page":"3788","volume-title":"Genes Dev.","year":"1998"},{"key":"2026012810562465100_R2","first-page":"631","volume-title":"Annu. 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