{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:51:30Z","timestamp":1791010290253,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Severe infections with Streptococcus pyogenes, an important human pathogen, are associated with massive inflammatory reactions in the human host. Here we show that streptococcal M protein interacts with TLR2 on human peripheral blood monocytes. As a consequence, monocytes express the cytokines IL-6, IL-1\u03b2, and TNF-\u03b1. This response is significantly increased in the presence of neutrophil-derived heparin-binding protein (HBP), which costimulates monocytes by interacting with CD11\/CD18. Analysis of tissue biopsies from patients with necrotizing fasciitis revealed recruitment of neutrophils and monocytes to the infectious site, combined with the release of HBP. The results show that M protein, in synergy with HBP, evokes an inflammatory response that may contribute to the profound pathophysiological consequences seen in severe streptococcal infections.<\/jats:p>","DOI":"10.4049\/jimmunol.177.2.1221","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:19:01Z","timestamp":1397863141000},"page":"1221-1228","source":"Crossref","is-referenced-by-count":128,"title":["Streptococcal M Protein: A Multipotent and Powerful Inducer of Inflammation"],"prefix":"10.1093","volume":"177","author":[{"given":"Lisa I","family":"Pa\u030ahlman","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University , Lund ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Mo\u0308rgelin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University , Lund ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Eckert","sequence":"additional","affiliation":[{"name":"Institute for Microbiology and Hygiene, Charite\u0301 University Medical Center, Humboldt University , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Johansson","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Center for Infectious Medicine, Huddinge University Hospital , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University , Lund ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Riesbeck","sequence":"additional","affiliation":[{"name":"Medical Microbiology, Department of Laboratory Medicine, Malmo\u0308 University Hospital, Lund University , Malmo\u0308 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Soehnlein","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Lindbom","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Norrby-Teglund","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Center for Infectious Medicine, Huddinge University Hospital , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf R","family":"Schumann","sequence":"additional","affiliation":[{"name":"Institute for Microbiology and Hygiene, Charite\u0301 University Medical Center, Humboldt University , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Bjo\u0308rck","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University , Lund ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Herwald","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University , Lund ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,7,15]]},"reference":[{"key":"2025032613395540300_R1","first-page":"25","volume-title":"Curr. Opin. Microbiol.","year":"2004"},{"key":"2025032613395540300_R2","first-page":"197","volume-title":"Annu. Rev. Immunol.","year":"2002"},{"key":"2025032613395540300_R3","first-page":"971","volume-title":"Nat. Immunol.","year":"2004"},{"key":"2025032613395540300_R4","first-page":"927","volume-title":"Cell.","year":"2002"},{"key":"2025032613395540300_R5","first-page":"1099","volume-title":"Mol. Immunol.","year":"2004"},{"key":"2025032613395540300_R6","first-page":"555","volume-title":"Scand. J. Infect. Dis.","year":"2003"},{"key":"2025032613395540300_R7","first-page":"845","volume-title":"Mol. Immunol.","year":"2004"},{"key":"2025032613395540300_R8","first-page":"143","volume-title":"Cell. Microbiol.","year":"2003"},{"key":"2025032613395540300_R9","first-page":"861","volume-title":"Mol. Immunol.","year":"2004"},{"key":"2025032613395540300_R10","first-page":"987","volume-title":"Nat. Immunol.","year":"2004"},{"key":"2025032613395540300_R11","first-page":"514","volume-title":"J. Leukocyte Biol.","year":"2004"},{"key":"2025032613395540300_R12","first-page":"535","volume-title":"Scand. J. Infect. Dis.","year":"2003"},{"key":"2025032613395540300_R13","first-page":"379","volume-title":"Curr. Infect. Dis. Rep.","year":"2003"},{"key":"2025032613395540300_R14","first-page":"470","volume-title":"Clin. Microbiol. Rev.","year":"2000"},{"key":"2025032613395540300_R15","first-page":"367","volume-title":"Cell","year":"2004"},{"key":"2025032613395540300_R16","first-page":"161","volume-title":"J. Gen. Microbiol.","year":"1969"},{"key":"2025032613395540300_R17","first-page":"285","volume-title":"Clin. Microbiol. Rev.","year":"1989"},{"key":"2025032613395540300_R18","first-page":"877","volume-title":"Biochem. J.","year":"1994"},{"key":"2025032613395540300_R19","first-page":"9862","volume-title":"J. Biol. Chem.","year":"1995"},{"key":"2025032613395540300_R20","first-page":"1306","volume-title":"Mol. Microbiol.","year":"2000"},{"key":"2025032613395540300_R21","first-page":"3798","volume-title":"J. Immunol.","year":"2004"},{"key":"2025032613395540300_R22","first-page":"1607","volume-title":"EMBO J.","year":"2002"},{"key":"2025032613395540300_R23","first-page":"4211","volume-title":"Microbiology","year":"2004"},{"key":"2025032613395540300_R24","first-page":"12147","volume-title":"J. Biol. Chem.","year":"1994"},{"key":"2025032613395540300_R25","first-page":"16561","volume-title":"J. Biol. Chem.","year":"2003"},{"key":"2025032613395540300_R26","first-page":"109","volume-title":"FEBS Lett.","year":"1996"},{"key":"2025032613395540300_R27","first-page":"456","volume-title":"Int. J. Cancer","year":"1988"},{"key":"2025032613395540300_R28","first-page":"1","volume-title":"J. Immunol.","year":"1999"},{"key":"2025032613395540300_R29","first-page":"926","volume-title":"J. Infect. Dis.","year":"2001"},{"key":"2025032613395540300_R30","first-page":"1123","volume-title":"Nat. Med.","year":"2001"},{"key":"2025032613395540300_R31","first-page":"313","volume-title":"J. Electron Microsc. Tech.","year":"1990"},{"key":"2025032613395540300_R32","first-page":"125","volume-title":"J. Microsc.","year":"1986"},{"key":"2025032613395540300_R33","first-page":"853","volume-title":"J. Infect. Dis.","year":"2001"},{"key":"2025032613395540300_R34","first-page":"634","volume-title":"J. Leukocyte Biol.","year":"1999"},{"key":"2025032613395540300_R35","first-page":"1704","volume-title":"Blood","year":"1989"},{"key":"2025032613395540300_R36","first-page":"299","volume-title":"Microb. Pathog.","year":"1995"},{"key":"2025032613395540300_R37","first-page":"4240","volume-title":"J. Immunol.","year":"1999"},{"key":"2025032613395540300_R38","first-page":"1213","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2025032613395540300_R39","first-page":"D438","volume-title":"Front. Biosci.","year":"2000"},{"key":"2025032613395540300_R40","first-page":"1044","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1991"},{"key":"2025032613395540300_R41","first-page":"1102","volume-title":"Plant Physiol.","year":"2002"},{"key":"2025032613395540300_R42","first-page":"172","volume-title":"Cytometry","year":"2001"},{"key":"2025032613395540300_R43","first-page":"885","volume-title":"Nature","year":"2002"},{"key":"2025032613395540300_R44","first-page":"1665","volume-title":"Science","year":"1994"},{"key":"2025032613395540300_R45","first-page":"271","volume-title":"Annu. Rev. Med.","year":"2000"},{"key":"2025032613395540300_R46","first-page":"25","volume-title":"Curr. Opin. Hematol.","year":"2003"},{"key":"2025032613395540300_R47","first-page":"485","volume-title":"Scand. J. Infect. Dis.","year":"2004"},{"key":"2025032613395540300_R48","first-page":"121","volume-title":"Curr. Top. Microbiol. Immunol.","year":"2002"},{"key":"2025032613395540300_R49","first-page":"1473","volume-title":"J. Clin. Invest.","year":"2004"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/177\/2\/1221\/62643801\/zim01406001221.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/177\/2\/1221\/62643801\/zim01406001221.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T15:30:59Z","timestamp":1743262259000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/177\/2\/1221\/8028794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,7,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.177.2.1221","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2006,7]]},"published":{"date-parts":[[2006,7]]}}}