{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:35:04Z","timestamp":1771806904271,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Zinc (Zn) is an essential nutrient, and its deficiency causes growth retardation, immunodeficiency, and neuronal degeneration. However, the precise roles and molecular mechanism(s) of Zn function in immune response have not been clarified. Mast cells (MCs) are granulated cells that play a pivotal role in allergic reactions and inflammation. The granules of MCs contain various chemical mediators and inflammatory cytokines that are released upon Fc\u03b5RI cross-linking. In this study, we report that Zn is essential for MC activation both in vitro and in vivo. We showed that a Zn chelator, N,N,N,N-tetrakis (2-pyridylmethyl) ethylenediamine, inhibited in vivo allergic reactions such as PCA and PSA. Consistent with this, N,N,N,N-tetrakis (2-pyridylmethyl) ethylenediamine significantly inhibited the Fc\u03b5RI-induced degranulation and cytokine production. We found that Zn was required for Fc\u03b5RI-induced translocation of granules to the plasma membrane, a process that we have shown to be important for MC degranulation. In addition, we showed that Zn was essential for plasma membrane translocation of protein kinase C and subsequent nuclear translocation of NF-\u03baB, leading to cytokine production, such as IL-6 and TNF-\u03b1. These results revealed that Zn was involved in multiple steps of Fc\u03b5RI-induced MC activation and required for degranulation and cytokine production.<\/jats:p>","DOI":"10.4049\/jimmunol.177.2.1296","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:19:01Z","timestamp":1397863141000},"page":"1296-1305","source":"Crossref","is-referenced-by-count":116,"title":["Zinc Is Required for Fc\u03b5RI-Mediated Mast Cell Activation"],"prefix":"10.1093","volume":"177","author":[{"given":"Koki","family":"Kabu","sequence":"first","affiliation":[{"name":"Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology (RCAI) , Yokohama, Kanagawa ,","place":["Japan"]},{"name":"Laboratories of Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University , Osaka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology (RCAI) , Yokohama, Kanagawa ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kamimura","sequence":"additional","affiliation":[{"name":"Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology (RCAI) , Yokohama, Kanagawa ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukitaka","family":"Ito","sequence":"additional","affiliation":[{"name":"Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology (RCAI) , Yokohama, Kanagawa ,","place":["Japan"]},{"name":"Laboratories of Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University , Osaka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiko","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology (RCAI) , Yokohama, Kanagawa ,","place":["Japan"]},{"name":"Laboratories of Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University , Osaka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi","family":"Sato","sequence":"additional","affiliation":[{"name":"Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology (RCAI) , Yokohama, Kanagawa ,","place":["Japan"]},{"name":"Laboratories of Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University , Osaka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemitsu","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology (RCAI) , Yokohama, Kanagawa ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keigo","family":"Nishida","sequence":"additional","affiliation":[{"name":"Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology (RCAI) , Yokohama, Kanagawa ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Hirano","sequence":"additional","affiliation":[{"name":"Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology (RCAI) , Yokohama, Kanagawa ,","place":["Japan"]},{"name":"Laboratories of Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University , Osaka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,7,15]]},"reference":[{"key":"2025032613394823100_R1","first-page":"63","volume-title":"Mol. 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