{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:27:51Z","timestamp":1762252071254,"version":"3.40.3"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Prolactin is of interest in the pathogenesis of systemic lupus erythematosus (SLE) because almost 25% of SLE patients display hyperprolactinemia, and serum prolactin correlates with disease activity in some patients. Furthermore, hyperprolactinemia causes early mortality in lupus-prone mice and induces a lupus-like phenotype in nonspontaneously autoimmune mice. We show here that the immunomodulatory effects of prolactin are genetically determined; hyperprolactinemia breaks B cell tolerance and causes a lupus-like serology in BALB\/c mice expressing a transgene encoding the H chain of an anti-DNA Ab but not in C57BL\/6 transgenic mice. In C57BL\/6 mice that express both the H chain transgene and the lupus susceptibility interval Sle3\/5, prolactin induces increased serum titers of anti-DNA Ab and glomerular Ig depositions. The increase in costimulation due to prolactin-mediated up-regulation of both CD40 on B cells and CD40L on T cells would appear to play a central role in lupus induction in this model.<\/jats:p>","DOI":"10.4049\/jimmunol.177.3.1401","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T16:59:02Z","timestamp":1398358742000},"page":"1401-1405","source":"Crossref","is-referenced-by-count":23,"title":["Cutting Edge: Lupus Susceptibility Interval <i>Sle3\/5<\/i> Confers Responsiveness to Prolactin in C57BL\/6 Mice"],"prefix":"10.1093","volume":"177","author":[{"given":"Elena","family":"Peeva","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juana","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruthmarie","family":"Hicks","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, NY 10461"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betty","family":"Diamond","sequence":"additional","affiliation":[{"name":"Department of Medicine and Microbiology, Columbia University Medical Center , New York, NY 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,8,1]]},"reference":[{"first-page":"352","volume-title":"Curr. 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