{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T01:48:17Z","timestamp":1770083297959,"version":"3.49.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Memory CD8 T cells respond more rapidly to acute intracellular infections than naive CD8 T cells. An understanding of the biological processes involved in memory CD8 T cell recognition of Ag and up-regulation of effector mechanism necessitates analyzing memory CD8 T cells at early time points after infection. In the current study, we show that memory CD8 T cells ostensibly disappear from the spleens, blood, and peripheral organs of mice early after infection with Listeria monocytogenes. This disappearance is critically dependent on Ag, and cell-associated Ag alone can mediate this phenomenon. Further investigations, however, suggest that this disappearance is secondary to T cell-APC interactions, also known as T cell conditioning, and disruption of these putative interactions during splenic processing improves recovery of Ag-specific memory CD8 T cell populations after immunization. Conventional analyses of memory CD8 T cell populations early after infection and possibly in the presence of low levels of Ag (as during chronic infections) may exclude significant numbers of the responding CD8 T cell population.<\/jats:p>","DOI":"10.4049\/jimmunol.177.5.3012","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:38:50Z","timestamp":1397849930000},"page":"3012-3018","source":"Crossref","is-referenced-by-count":14,"title":["T Cell Conditioning Explains Early Disappearance of the Memory CD8 T Cell Response to Infection"],"prefix":"10.1093","volume":"177","author":[{"given":"Ali","family":"Jabbari","sequence":"first","affiliation":[{"name":"Interdisciplinary Graduate Program in Immunology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa , Iowa City, IA 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin L","family":"Legge","sequence":"additional","affiliation":[{"name":"Interdisciplinary Graduate Program in Immunology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa , Iowa City, IA 52242"},{"name":"Department of Pathology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa , Iowa City, IA 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T","family":"Harty","sequence":"additional","affiliation":[{"name":"Interdisciplinary Graduate Program in Immunology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa , Iowa City, IA 52242"},{"name":"Department of Microbiology, Roy J. and Lucille A. 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