{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:26:57Z","timestamp":1790922417233,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic malaria infection is characterized by polyclonal B cell activation, hyperglobulinemia, and elevated titers of autoantibodies. We have recently identified the cysteine-rich interdomain region 1\u03b1 (CIDR1\u03b1) of the Plasmodium falciparum erythrocyte membrane protein 1 as a T cell-independent polyclonal B cell activator and Ig binding protein. Here, we show that, although the binding affinity of CIDR1\u03b1 to human IgM and IgG is relatively low, B cell activation still proceeds. CIDR1\u03b1 rescues tonsillar B cells from apoptosis, and increases the proportion of cycling cells. Comparison of the impact on naive and memory B cell compartment indicated that CIDR1\u03b1 preferentially activates memory B lymphocytes. Analysis of the gene expression profiles induced by CIDR1\u03b1 and anti-Ig activation using a cDNA microarray demonstrated a low degree of homology in the signatures imposed by both stimuli. The microarray data correlate with the functional analysis demonstrating that CIDR1\u03b1 activates various immunological pathways and protects B cells from apoptosis. Together, the results provide evidence for a role of malaria in preferentially activating the memory B cell compartment. The polyclonal B cell activation and augmented survival induced by CIDR1\u03b1 is of relevance for understanding the mechanisms behind the increased risk of Burkitt\u2019s lymphoma in malaria endemic areas.<\/jats:p>","DOI":"10.4049\/jimmunol.177.5.3035","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:38:50Z","timestamp":1397849930000},"page":"3035-3044","source":"Crossref","is-referenced-by-count":77,"title":["Increased B Cell Survival and Preferential Activation of the Memory Compartment by a Malaria Polyclonal B Cell Activator"],"prefix":"10.1093","volume":"177","author":[{"given":"Daria","family":"Donati","sequence":"first","affiliation":[{"name":"Center for Infectious Medicine, Department of Medicine , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobo","family":"Mok","sequence":"additional","affiliation":[{"name":"Microbiology and Tumorbiology Center, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Che\u0302ne","sequence":"additional","affiliation":[{"name":"Microbiology and Tumorbiology Center, Karolinska Institutet , Stockholm ,","place":["Sweden"]},{"name":"Center for Infectious Medicine, Department of Medicine , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xu","sequence":"additional","affiliation":[{"name":"Center for Infectious Medicine, Department of Medicine , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathula","family":"Thangarajh","sequence":"additional","affiliation":[{"name":"Division of Neurology R54, Karolinska Institutet, Karolinska University Hospital Huddinge , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rickard","family":"Glas","sequence":"additional","affiliation":[{"name":"Center for Infectious Medicine, Department of Medicine , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijun","family":"Chen","sequence":"additional","affiliation":[{"name":"Swedish Institute for Infection Disease Control , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Wahlgren","sequence":"additional","affiliation":[{"name":"Microbiology and Tumorbiology Center, Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Bejarano","sequence":"additional","affiliation":[{"name":"Microbiology and Tumorbiology Center, Karolinska Institutet , Stockholm ,","place":["Sweden"]},{"name":"Center for Infectious Medicine, Department of Medicine , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,9,1]]},"reference":[{"key":"2026020208173522400_R1","first-page":"191","volume-title":"Am. 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