{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T02:08:55Z","timestamp":1770084535198,"version":"3.49.0"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Better understanding of tolerance and autoimmunity toward melanocyte-specific Ags is needed to develop effective treatment for vitiligo and malignant melanoma; yet, a systematic assessment of these mechanisms has been hampered by the difficulty in tracking autoreactive T cells. To address this issue, we have generated transgenic mice that express hen egg lysozyme as a melanocyte-specific neoantigen. By crossing these animals to a hen egg lysozyme-specific CD4 TCR transgenic line we have been able to track autoreactive CD4+ T cells from their development in the thymus to their involvement in spontaneous autoimmune disease with striking similarity to human vitiligo vulgaris and Vogt-Koyanagi-Harada syndrome. Our findings show that CD4-dependent destruction of melanocytes is partially inhibited by blocking Fas-Fas ligand interactions and also highlights the importance of local control of autoimmunity, as vitiligo remains patchy and never proceeds to confluence even when Ag and autoreactive CD4+ T cells are abundant. Immune therapy to enhance or suppress melanocyte-specific T cells can be directed at a series of semiredundant pathways involving tolerance and cell death.<\/jats:p>","DOI":"10.4049\/jimmunol.177.5.3055","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:38:50Z","timestamp":1397849930000},"page":"3055-3062","source":"Crossref","is-referenced-by-count":66,"title":["CD4 T Cell-Dependent Autoimmunity against a Melanocyte Neoantigen Induces Spontaneous Vitiligo and Depends upon Fas-Fas Ligand Interactions"],"prefix":"10.1093","volume":"177","author":[{"given":"Teresa","family":"Lambe","sequence":"first","affiliation":[{"name":"Henry Wellcome Building of Molecular Physiology, University of Oxford , Oxford ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janson C H","family":"Leung","sequence":"additional","affiliation":[{"name":"Henry Wellcome Building of Molecular Physiology, University of Oxford , Oxford ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiphaine","family":"Bouriez-Jones","sequence":"additional","affiliation":[{"name":"Henry Wellcome Building of Molecular Physiology, University of Oxford , Oxford ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karlee","family":"Silver","sequence":"additional","affiliation":[{"name":"Henry Wellcome Building of Molecular Physiology, University of Oxford , Oxford ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimmo","family":"Makinen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Aberdeen , Aberdeen ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya L","family":"Crockford","sequence":"additional","affiliation":[{"name":"Henry Wellcome Building of Molecular Physiology, University of Oxford , Oxford ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Ferry","sequence":"additional","affiliation":[{"name":"Henry Wellcome Building of Molecular Physiology, University of Oxford , Oxford ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John V","family":"Forrester","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Aberdeen , Aberdeen ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J","family":"Cornall","sequence":"additional","affiliation":[{"name":"Henry Wellcome Building of Molecular Physiology, University of Oxford , Oxford ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,9,1]]},"reference":[{"key":"2026020208174702000_R1","first-page":"545","volume-title":"The Autoimmune Diseases","year":"1998"},{"key":"2026020208174702000_R2","first-page":"285","volume-title":"J. 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