{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T21:54:43Z","timestamp":1782251683144,"version":"3.54.5"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bullous pemphigoid (BP) is a bullous dermatosis associated with autoantibodies directed against the hemidesmosomal Ags BP180 and BP230. Lesional skin is characterized by detachment of the epidermis from the dermis with an intense inflammatory cell infiltrate in the upper dermis. In experimental BP, subepidermal blistering is triggered by rabbit anti-murine BP180 (mBP180) IgG and depends upon complement activation, mast cell degranulation, and neutrophil infiltration. In this study, we determined the role of Fc\u03b3Rs on neutrophils in experimental BP. Mice deficient in Fc\u03b3RIII (Fc\u03b3RIII\u2212\/\u2212) and those deficient in both Fc\u03b3RI and Fc\u03b3RIII (Fc\u03b3RI&amp;III\u2212\/\u2212) but not in Fc\u03b3RII (Fc\u03b3RII\u2212\/\u2212) were resistant to BP. Pathogenic IgG activated wild-type neutrophils, but not Fc\u03b3RIII-deficient neutrophils, to secrete proteolytic enzymes. The function of anti-mBP180 IgG depended entirely on its Fc domain; F(ab\u2032)2 of IgG had no pathogenic activities. In wild-type mice injected with pathogenic IgG, an Fc\u03b3R blocker abolished the BP phenotype and inhibited activation of wild-type neutrophils stimulated by pathogenic IgG. Results from this study establish that Fc\u03b3RIII plays a critical role in the activation of infiltrating neutrophils and the subsequent blistering in experimental BP.<\/jats:p>","DOI":"10.4049\/jimmunol.177.5.3398","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:38:50Z","timestamp":1397849930000},"page":"3398-3405","source":"Crossref","is-referenced-by-count":55,"title":["Role of FcRs in Animal Model of Autoimmune Bullous Pemphigoid"],"prefix":"10.1093","volume":"177","author":[{"given":"Minglang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of North Carolina School of Medicine , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E","family":"Trimbeger","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of North Carolina School of Medicine , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of North Carolina School of Medicine , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A","family":"Diaz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of North Carolina School of Medicine , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of North Carolina School of Medicine , Chapel Hill, NC 27599"},{"name":"Department of Microbiology and Immunology, University of North Carolina School of Medicine , Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,9,1]]},"reference":[{"key":"2026020208192365600_R1","first-page":"1","volume-title":"Medicine","year":"1953"},{"key":"2026020208192365600_R2","first-page":"483","volume-title":"Dermatologic Clin.","year":"1993"},{"key":"2026020208192365600_R3","first-page":"666","volume-title":"Fitzpatrick\u2019s Dermatology in General Medicine","year":"1999"},{"key":"2026020208192365600_R4","first-page":"243","volume-title":"J. 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