{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:15:29Z","timestamp":1791213329057,"version":"4.1.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Human lactoferrin (Lf) is an iron binding glycoprotein that is present in several mucosal secretions. Many biological functions have been ascribed to Lf. In the present study, we showed that Lf limited specifically adsorption of R5- and X4-HIV-1-free particles on endometrial epithelial HEC-1A cells, by inhibiting virus adsorption on heparan-sulfated proteoglycans. But, Lf did not interfere with both R5 and X4-HIV transcytosis. We showed also the efficacy of Lf in preventing R5 and X4-HIV capture by dendritic cells. Conversely, we demonstrated that Lf-reacting natural Abs (NAbs) present within i.v. Ig-enhanced HIV attachment on dendritic cells by forming HIV-Lf-NAbs. HIV particles were able to directly interact with Lf following its interaction with NAbs. We also found Lf-reacting natural Abs within cervicovaginal secretions, suggesting the existence of Lf-NAbs complexes in women genital tract in vivo. In conclusion, this study highlights Lf as a potent microbicides and reports new function for NAbs within the genital compartment that may compartment that may abolish the inhibitory activity of microbicide compounds. Thus, we proposed a model in which Lf would appear as a double-edged sword that could have beneficial or detrimental effects depending on both cellular and molecular environments. This study highlights the use of Lf derivates as microbicide candidates to limit such interferences.<\/jats:p>","DOI":"10.4049\/jimmunol.177.8.5540","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:20:27Z","timestamp":1397848827000},"page":"5540-5549","source":"Crossref","is-referenced-by-count":28,"title":["Differential Modulation of Human Lactoferrin Activity against Both R5 and X4-HIV-1 Adsorption on Epithelial Cells and Dendritic Cells by Natural Antibodies"],"prefix":"10.1093","volume":"177","author":[{"given":"He\u0301la","family":"Saidi","sequence":"first","affiliation":[{"name":"Universite\u0301 Rene\u0301 Descartes Paris V, Unite\u0301 Institut National de la Recherche et de la Sante\u0301 (INSERM) Internationale 743 d\u2019Immunologie Humaine, Equipe Immunite\u0301 et Biothe\u0301rapie Muqueuse, Centres de Recherches Biome\u0301dicales des Cordeliers , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jobin","family":"Eslaphazir","sequence":"additional","affiliation":[{"name":"Universite\u0301 Rene\u0301 Descartes Paris V, Unite\u0301 Institut National de la Recherche et de la Sante\u0301 (INSERM) Internationale 743 d\u2019Immunologie Humaine, Equipe Immunite\u0301 et Biothe\u0301rapie Muqueuse, Centres de Recherches Biome\u0301dicales des Cordeliers , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce\u0301dric","family":"Carbonneil","sequence":"additional","affiliation":[{"name":"Universite\u0301 Rene\u0301 Descartes Paris V, Unite\u0301 Institut National de la Recherche et de la Sante\u0301 (INSERM) Internationale 743 d\u2019Immunologie Humaine, Equipe Immunite\u0301 et Biothe\u0301rapie Muqueuse, Centres de Recherches Biome\u0301dicales des Cordeliers , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Carthagena","sequence":"additional","affiliation":[{"name":"Universite\u0301 Rene\u0301 Descartes Paris V, Unite\u0301 Institut National de la Recherche et de la Sante\u0301 (INSERM) Internationale 743 d\u2019Immunologie Humaine, Equipe Immunite\u0301 et Biothe\u0301rapie Muqueuse, Centres de Recherches Biome\u0301dicales des Cordeliers , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Requena","sequence":"additional","affiliation":[{"name":"Universite\u0301 Rene\u0301 Descartes Paris V, Unite\u0301 Institut National de la Recherche et de la Sante\u0301 (INSERM) Internationale 743 d\u2019Immunologie Humaine, Equipe Immunite\u0301 et Biothe\u0301rapie Muqueuse, Centres de Recherches Biome\u0301dicales des Cordeliers , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Nassreddine","sequence":"additional","affiliation":[{"name":"Universite\u0301 Rene\u0301 Descartes Paris V, Unite\u0301 Institut National de la Recherche et de la Sante\u0301 (INSERM) Internationale 743 d\u2019Immunologie Humaine, Equipe Immunite\u0301 et Biothe\u0301rapie Muqueuse, Centres de Recherches Biome\u0301dicales des Cordeliers , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Belec","sequence":"additional","affiliation":[{"name":"Universite\u0301 Rene\u0301 Descartes Paris V, Unite\u0301 Institut National de la Recherche et de la Sante\u0301 (INSERM) Internationale 743 d\u2019Immunologie Humaine, Equipe Immunite\u0301 et Biothe\u0301rapie Muqueuse, Centres de Recherches Biome\u0301dicales des Cordeliers , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,10,15]]},"reference":[{"key":"2026020211114487200_R1","first-page":"1072","volume-title":"N. Engl. J. Med.","year":"1997"},{"key":"2026020211114487200_R2","first-page":"5370","volume-title":"J. Virol.","year":"2001"},{"key":"2026020211114487200_R3","first-page":"215","volume-title":"J. Exp. Med.","year":"1996"},{"key":"2026020211114487200_R4","first-page":"587","volume-title":"Cell","year":"2000"},{"key":"2026020211114487200_R5","first-page":"158","volume-title":"R. Soc. Med.","year":"2003"},{"key":"2026020211114487200_R6","first-page":"977","volume-title":"Nat. Rev. Drug Discov.","year":"2002"},{"key":"2026020211114487200_R7","first-page":"420","volume-title":"J. Antimicrob. Chemother.","year":"2005"},{"key":"2026020211114487200_R8","first-page":"264","volume-title":"Virology","year":"2005"},{"key":"2026020211114487200_R9","first-page":"327","volume-title":"J. Acquir. Immune. Defic. Syndr. Hum. Retrovirol.","year":"1998"},{"key":"2026020211114487200_R10","first-page":"1","volume-title":"Biochemistry","year":"2001"},{"key":"2026020211114487200_R11","first-page":"735","volume-title":"Clin. Chim. Acta","year":"1966"},{"key":"2026020211114487200_R12","first-page":"419","volume-title":"Gynecol. Obstet.","year":"1969"},{"key":"2026020211114487200_R13","first-page":"285","volume-title":"J. Mammary Gland Biol. Neoplasia","year":"1996"},{"key":"2026020211114487200_R14","first-page":"657","volume-title":"Arch. Dis. Child","year":"1992"},{"key":"2026020211114487200_R15","first-page":"2688","volume-title":"Antimicrob. Agents Chemother.","year":"2003"},{"key":"2026020211114487200_R16","first-page":"284","volume-title":"Virology","year":"2005"},{"key":"2026020211114487200_R17","first-page":"116","volume-title":"Reprod. Biol. Endocrinol.","year":"2003"},{"key":"2026020211114487200_R18","first-page":"385","volume-title":"J. Infect. Dis.","year":"1989"},{"key":"2026020211114487200_R19","first-page":"691","volume-title":"J. Infect. Dis.","year":"1995"},{"key":"2026020211114487200_R20","first-page":"719","volume-title":"AIDS Res. Hum. Retroviruses","year":"1995"},{"key":"2026020211114487200_R21","first-page":"58","volume-title":"Am. J. Reprod. Immunol.","year":"1999"},{"key":"2026020211114487200_R22","first-page":"1412","volume-title":"J. Infect. Dis.","year":"2001"},{"key":"2026020211114487200_R23","first-page":"568","volume-title":"Cytokine","year":"1995"},{"key":"2026020211114487200_R24","first-page":"801","volume-title":"AIDS","year":"2001"},{"key":"2026020211114487200_R25","first-page":"9187","volume-title":"J. Virol.","year":"2001"},{"key":"2026020211114487200_R26","first-page":"7606","volume-title":"J. Immunol.","year":"2001"},{"key":"2026020211114487200_R27","first-page":"6058","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1990"},{"key":"2026020211114487200_R28","first-page":"63","volume-title":"Antiviral Res.","year":"2004"},{"key":"2026020211114487200_R29","first-page":"381","volume-title":"Viral Immunol.","year":"2004"},{"key":"2026020211114487200_R30","first-page":"21353","volume-title":"J. Biol. Chem.","year":"2005"},{"key":"2026020211114487200_R31","first-page":"483","volume-title":"Eur. J. Immunol.","year":"2003"},{"key":"2026020211114487200_R32","first-page":"71","volume-title":"Int. J. Immunopathol. Pharmacol.","year":"2001"},{"key":"2026020211114487200_R33","first-page":"1101","volume-title":"AIDS Res. Hum. Retroviruses","year":"1997"},{"key":"2026020211114487200_R34","first-page":"382","volume-title":"Eur. J. Cell Biol.","year":"1992"},{"key":"2026020211114487200_R35","first-page":"769","volume-title":"AIDS Res. Hum. Retroviruses","year":"1996"},{"key":"2026020211114487200_R36","first-page":"659","volume-title":"Eur. J. Biochem.","year":"1984"},{"key":"2026020211114487200_R37","first-page":"711","volume-title":"J. Mol. Biol.","year":"1989"},{"key":"2026020211114487200_R38","first-page":"8802","volume-title":"J. Biol. Chem.","year":"1997"},{"key":"2026020211114487200_R39","first-page":"23661","volume-title":"J. Biol. Chem.","year":"1994"},{"key":"2026020211114487200_R40","first-page":"139","volume-title":"J. Immunol. Methods","year":"2002"},{"key":"2026020211114487200_R41","first-page":"975","volume-title":"Nat. Immunol.","year":"2002"},{"key":"2026020211114487200_R42","first-page":"13519","volume-title":"J. Virol.","year":"2005"},{"key":"2026020211114487200_R43","first-page":"710","volume-title":"J. Leukocyte Biol.","year":"2003"},{"key":"2026020211114487200_R44","first-page":"303","volume-title":"Eur. J. Biochem.","year":"2004"},{"key":"2026020211114487200_R45","first-page":"1257","volume-title":"Curr. Pharm. Des.","year":"2003"},{"key":"2026020211114487200_R46","first-page":"291","volume-title":"Biometals","year":"2004"},{"key":"2026020211114487200_R47","first-page":"3009","volume-title":"J. Virol.","year":"2005"},{"key":"2026020211114487200_R48","first-page":"241","volume-title":"Mol. Immunol.","year":"2001"},{"key":"2026020211114487200_R49","first-page":"161","volume-title":"Curr. Top. Microbiol. Immunol.","year":"1995"},{"key":"2026020211114487200_R50","first-page":"4086","volume-title":"J. Virol.","year":"1997"},{"key":"2026020211114487200_R51","first-page":"1051","volume-title":"J. Infect. Dis.","year":"2000"},{"key":"2026020211114487200_R52","first-page":"7202","volume-title":"J. Immunol.","year":"2005"},{"key":"2026020211114487200_R53","first-page":"758","volume-title":"Blood","year":"2003"},{"key":"2026020211114487200_R54","first-page":"1725","volume-title":"Transplantation","year":"2006"},{"key":"2026020211114487200_R55","first-page":"71","volume-title":"Exp. Mol. Pathol.","year":"2001"},{"key":"2026020211114487200_R56","first-page":"3301","volume-title":"J. Immunol.","year":"2002"},{"key":"2026020211114487200_R57","first-page":"1002","volume-title":"Lancet","year":"2004"},{"key":"2026020211114487200_R58","first-page":"1303","volume-title":"J. Pharm. Pharmacol.","year":"2001"},{"key":"2026020211114487200_R59","first-page":"841","volume-title":"Expert Opin. Investig. Drugs","year":"2003"},{"key":"2026020211114487200_R60","first-page":"1469","volume-title":"Infect. Immun.","year":"2001"},{"key":"2026020211114487200_R61","first-page":"859","volume-title":"J. Reprod. Med.","year":"2004"},{"key":"2026020211114487200_R62","first-page":"153","volume-title":"Antiviral Res.","year":"2002"},{"key":"2026020211114487200_R63","first-page":"380","volume-title":"J. Infect. Dis.","year":"1995"},{"key":"2026020211114487200_R64","first-page":"1055","volume-title":"Int. J. Biochem. Cell Biol.","year":"1998"},{"key":"2026020211114487200_R65","first-page":"205","volume-title":"Adv. Exp. Med. Biol.","year":"1998"},{"key":"2026020211114487200_R66","first-page":"228","volume-title":"Hepatol. Res.","year":"2002"},{"key":"2026020211114487200_R67","first-page":"549","volume-title":"Biochem. Biophys. Res. Commun.","year":"1998"},{"key":"2026020211114487200_R68","first-page":"563","volume-title":"J. Pept. Sci.","year":"1999"},{"key":"2026020211114487200_R69","first-page":"1571","volume-title":"Arch. Virol.","year":"2000"},{"key":"2026020211114487200_R70","first-page":"1161","volume-title":"J. Infect. Dis.","year":"2002"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/177\/8\/5540\/62651468\/zim02006005540.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/177\/8\/5540\/62651468\/zim02006005540.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T16:11:46Z","timestamp":1770048706000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/177\/8\/5540\/8031522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":70,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2006,10,15]]},"published-print":{"date-parts":[[2006,10,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.177.8.5540","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2006,10]]},"published":{"date-parts":[[2006,10]]}}}