{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:40:23Z","timestamp":1791042023096,"version":"4.1.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CD4+CD25+FoxP3+ regulatory T cells are decreased in patients infected with HIV and have been shown to be critical in mediating Ag tolerance in the lung. Because a subset of Pneumocystis-infected individuals develop substantial lung injury, which can be modeled in immune reconstituted scid mice, we used mouse models of Pneumocystis carinii to investigate the role of regulatory T cells in opportunistic infection and immune reconstitution. In this study, we show that CD4+CD25+FoxP3+ cells are part of the host response to Pneumocystis in CD4+ T cell-intact mice. Moreover, lung injury and proinflammatory Th1 and Th2 cytokine levels in the bronchoalveolar lavage fluid and lung homogenate were increased following CD4+CD25\u2212 immune reconstitution in Pneumocystis-infected SCID mice but not in CD4+CD25+ T cell-reconstituted animals. The ability of CD4+CD25+ T cells to control inflammation and injury during the course of Pneumocystis was confirmed by treatment of wild-type C57BL\/6 mice with anti-CD25 mAb. These data show that CD4+CD25+ T cells control pulmonary inflammation and lung injury associated with Pneumocystis infection both in the setting of immune reconstitution as well as new acquisition of infection.<\/jats:p>","DOI":"10.4049\/jimmunol.177.9.6215","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:02:17Z","timestamp":1397847737000},"page":"6215-6226","source":"Crossref","is-referenced-by-count":98,"title":["Regulatory T Cells Dampen Pulmonary Inflammation and Lung Injury in an Animal Model of\n                    <i>Pneumocystis<\/i>\n                    Pneumonia"],"prefix":"10.1093","volume":"177","author":[{"given":"Laura","family":"McKinley","sequence":"first","affiliation":[{"name":"Department of Pediatrics, and Division of Pulmonary Medicine, Allergy, and Immunology, Children\u2019s Hospital of Pittsburgh, University of Pittsburgh School of Medicine , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison J","family":"Logar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, and Division of Pulmonary Medicine, Allergy, and Immunology, Children\u2019s Hospital of Pittsburgh, University of Pittsburgh School of Medicine , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"McAllister","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, and Division of Pulmonary Medicine, Allergy, and Immunology, Children\u2019s Hospital of Pittsburgh, University of Pittsburgh School of Medicine , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingquan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, and Division of Pulmonary Medicine, Allergy, and Immunology, Children\u2019s Hospital of Pittsburgh, University of Pittsburgh School of Medicine , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Steele","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, and Division of Pulmonary Medicine, Allergy, and Immunology, Children\u2019s Hospital of Pittsburgh, University of Pittsburgh School of Medicine , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay K","family":"Kolls","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, and Division of Pulmonary Medicine, Allergy, and Immunology, Children\u2019s Hospital of Pittsburgh, University of Pittsburgh School of Medicine , Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,11,1]]},"reference":[{"key":"2026020211140458800_R1","first-page":"1713","volume-title":"Emerging Infect. 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