{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:49:28Z","timestamp":1773290968427,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Microbial infections induce the replacement of constitutive proteasomes by immunoproteasomes (I-proteasomes). I-proteasomes support efficient generation of MHC class I epitopes and influence immunodominance hierarchies of CD8+ T cells. Recently, the function of I-proteasomes in antimicrobial responses was challenged by showing that the lack of I-proteasomes has no effect on induction and function of lymphocytic choriomeningitis virus-specific CD8+ T cells. Here, we show that infection with Listeria monocytogenes rapidly induces I-proteasomes in nonlymphoid tissues, which leads to enhanced generation of protection relevant CD8+ T cell epitopes. I-proteasome-deficient mice (\u03b25i\u2212\/\u2212 mice) exhibited normal frequencies of L. monocytogenes-specific CD8+ T cells. However, clearance of L. monocytogenes in liver but not spleen was significantly impaired in I-proteasome-deficient mice. In summary, our studies demonstrate that induction of I-proteasomes is required for CD8+ T cell-mediated elimination of L. monocytogenes from nonlymphoid but not lymphoid tissues.<\/jats:p>","DOI":"10.4049\/jimmunol.177.9.6238","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:02:17Z","timestamp":1397847737000},"page":"6238-6244","source":"Crossref","is-referenced-by-count":43,"title":["Immunoproteasomes Are Essential for Clearance of\n                    <i>Listeria monocytogenes<\/i>\n                    in Nonlymphoid Tissues but Not for Induction of Bacteria-Specific CD8+ T Cells"],"prefix":"10.1093","volume":"177","author":[{"given":"Britta","family":"Strehl","sequence":"first","affiliation":[{"name":"Institut fu\u0308r Biochemie, Charite\u0301-Universita\u0308tsmedizin , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"Joeris","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Rieger","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Biochemie, Charite\u0301-Universita\u0308tsmedizin , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Visekruna","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Textoris-Taube","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Biochemie, Charite\u0301-Universita\u0308tsmedizin , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan H E","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter-Michael","family":"Kloetzel","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Biochemie, Charite\u0301-Universita\u0308tsmedizin , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Kuckelkorn","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Biochemie, Charite\u0301-Universita\u0308tsmedizin , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Steinhoff","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute for Infection Biology , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,11,1]]},"reference":[{"key":"2026020211141745000_R1","first-page":"97","volume-title":"J. 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