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Although previous work on experimental CM has identified T cells as key mediators of pathology, the APCs and subsets therein required to initiate immunopathology remain unknown. In this study, we show that conventional dendritic cells but not plasmacytoid dendritic cells are required for the induction of malaria parasite-specific CD4+ T cell responses and subsequent experimental CM. These data have important implications for the development of malaria vaccines and the therapeutic management of CM.<\/jats:p>","DOI":"10.4049\/jimmunol.178.10.6033","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T22:53:28Z","timestamp":1397861608000},"page":"6033-6037","source":"Crossref","is-referenced-by-count":101,"title":["Cutting Edge: Conventional Dendritic Cells Are the Critical APC Required for the Induction of Experimental Cerebral Malaria"],"prefix":"10.1093","volume":"178","author":[{"given":"Saskia","family":"deWalick","sequence":"first","affiliation":[{"name":"Queensland Institute of Medical Research , Herston ,","place":["Australia"]},{"name":"Leiden University Medical Centre , Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona H","family":"Amante","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research , Herston ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karli A","family":"McSweeney","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research , Herston ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise M","family":"Randall","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research , Herston ,","place":["Australia"]},{"name":"School of Population Health, University of Queensland , Herston ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda C","family":"Stanley","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research , Herston ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraful","family":"Haque","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research , Herston ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel D","family":"Kuns","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research , Herston ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli P A","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research , Herston ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoff R","family":"Hill","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research , Herston ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian R","family":"Engwerda","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research , Herston ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,5,15]]},"reference":[{"key":"2025032702492811200_R1","first-page":"S1","volume-title":"Trans. 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