{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:45:08Z","timestamp":1791027908625,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although dysfunctional dendritic cells contribute to inadequate adaptive immunity in chronic hepatitis B (CHB), underlying molecular mechanisms remain largely undefined. In this study, we examined B7-H1 expression on circulating myeloid dendritic cells (mDCs) in 46 CHB patients, 10 autoimmune hepatitis patients, and 10 healthy subjects as control. We found that B7-H1 expression is significantly up-regulated on circulating mDCs of CHB and autoimmune hepatitis patients compared with healthy individuals. The B7-H1 up-regulation was significantly correlated with an elevation of serum alanine aminotransaminase levels and plasma viral load. In addition, in vitro, both IFN-\u03b1 and IFN-\u03b3 could strongly stimulate mDCs to express B7-H1. More importantly, elevated B7-H1 expression is also closely associated with the suppression of T cell immune function. In vitro blockade of B7-H1 signaling could not only down-regulate IL-10 and up-regulate IL-12 production by mDCs, but also enhance mDC-mediated allostimulatory capacity and cytokine production of T cells. Blockade of B7-H1 signaling could improve hepatitis B c Ag-pulsed monocyte-derived DC-induced IFN-\u03b3 production by autologous hepatitis B virus-specific T cells. These new findings suggested that chronic inflammation may contribute to B7-H1 up-regulation on mDCs in CHB patients, which potentially cause defective hepatitis B virus-specific T cell function and viral persistence. Our findings further support the notion that the blockade of B7-H1 may represent a novel therapeutic approach for this disease.<\/jats:p>","DOI":"10.4049\/jimmunol.178.10.6634","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T18:53:28Z","timestamp":1397847208000},"page":"6634-6641","source":"Crossref","is-referenced-by-count":107,"title":["B7-H1 Up-Regulation on Myeloid Dendritic Cells Significantly Suppresses T Cell Immune Function in Patients with Chronic Hepatitis B"],"prefix":"10.1093","volume":"178","author":[{"given":"Liangen","family":"Chen","sequence":"first","affiliation":[{"name":"Research Center of Biological Therapy, Beijing 302 Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center of Biological Therapy, Beijing 302 Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Research Center of Biological Therapy, Beijing 302 Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggang","family":"Li","sequence":"additional","affiliation":[{"name":"Research Center of Biological Therapy, Beijing 302 Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Shi","sequence":"additional","affiliation":[{"name":"Research Center of Biological Therapy, Beijing 302 Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center of Biological Therapy, Beijing 302 Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieping","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences ,","place":["China"]},{"name":"Department of Dermatology, Department of Oncology, and the Institute for Cell Engineering, Johns Hopkins University School of Medicine , Baltimore, MD 21231"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengdian","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Sheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center of Biological Therapy, Beijing 302 Hospital , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,5,15]]},"reference":[{"key":"2025032702491590000_R1","first-page":"23","volume-title":"Annu. Rev. Pathol. Mech. Dis.","year":"2006"},{"key":"2025032702491590000_R2","first-page":"215","volume-title":"Nat. Rev. Immunol.","year":"2005"},{"key":"2025032702491590000_R3","first-page":"1117","volume-title":"Hepatology","year":"2000"},{"key":"2025032702491590000_R4","first-page":"1269","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2025032702491590000_R5","first-page":"8609","volume-title":"J. Virol.","year":"2002"},{"key":"2025032702491590000_R6","first-page":"771","volume-title":"Hepatology","year":"2005"},{"key":"2025032702491590000_R7","first-page":"739","volume-title":"J. Immunol.","year":"2006"},{"key":"2025032702491590000_R8","first-page":"245","volume-title":"Nature","year":"1998"},{"key":"2025032702491590000_R9","first-page":"259","volume-title":"Cell","year":"2001"},{"key":"2025032702491590000_R10","first-page":"295","volume-title":"Int. J. Mol. Med.","year":"2004"},{"key":"2025032702491590000_R11","first-page":"1359","volume-title":"Nat. Med.","year":"2004"},{"key":"2025032702491590000_R12","first-page":"1806","volume-title":"World J. Gastroenterol.","year":"2005"},{"key":"2025032702491590000_R13","first-page":"296","volume-title":"Lancet Infect. Dis.","year":"2005"},{"key":"2025032702491590000_R14","first-page":"5644","volume-title":"J. Immunol.","year":"2006"},{"key":"2025032702491590000_R15","first-page":"643","volume-title":"Hepatology","year":"2005"},{"key":"2025032702491590000_R16","first-page":"335","volume-title":"Hepatology","year":"2004"},{"key":"2025032702491590000_R17","first-page":"637","volume-title":"J. Clin. Immunol.","year":"2004"},{"key":"2025032702491590000_R18","first-page":"738","volume-title":"Hepatology","year":"2004"},{"key":"2025032702491590000_R19","first-page":"217","volume-title":"J. Viral Hepat.","year":"2004"},{"key":"2025032702491590000_R20","first-page":"336","volume-title":"Nat. Rev. Immunol.","year":"2004"},{"key":"2025032702491590000_R21","first-page":"265","volume-title":"Trends Immunol.","year":"2000"},{"key":"2025032702491590000_R22","first-page":"1365","volume-title":"Nat. Med.","year":"1999"},{"key":"2025032702491590000_R23","first-page":"8291","volume-title":"J. Immunol.","year":"2006"},{"key":"2025032702491590000_R24","first-page":"2472","volume-title":"Eur. J. Immunol.","year":"2006"},{"key":"2025032702491590000_R25","first-page":"1257","volume-title":"J. Immunol.","year":"2003"},{"key":"2025032702491590000_R26","first-page":"281","volume-title":"J. Mol. Med.","year":"2003"},{"key":"2025032702491590000_R27","first-page":"562","volume-title":"Nat. Med.","year":"2003"},{"key":"2025032702491590000_R28","first-page":"2223","volume-title":"J. Exp. Med.","year":"2006"},{"key":"2025032702491590000_R29","first-page":"669","volume-title":"Nature","year":"2006"},{"key":"2025032702491590000_R30","first-page":"2514","volume-title":"Blood","year":"2003"},{"key":"2025032702491590000_R31","first-page":"350","volume-title":"Nature","year":"2006"},{"key":"2025032702491590000_R32","first-page":"2281","volume-title":"J. Exp. Med.","year":"2006"},{"key":"2025032702491590000_R33","first-page":"1198","volume-title":"Nat. Med.","year":"2006"},{"key":"2025032702491590000_R34","first-page":"3532","volume-title":"J. Virol.","year":"2006"},{"key":"2025032702491590000_R35","first-page":"725","volume-title":"J. Viral Hepat.","year":"2006"},{"key":"2025032702491590000_R36","first-page":"11398","volume-title":"J. Virol.","year":"2006"},{"key":"2025032702491590000_R37","first-page":"173","volume-title":"Clin. Immunol.","year":"2007"},{"key":"2025032702491590000_R38","first-page":"209","volume-title":"Immunol. Lett.","year":"2005"},{"key":"2025032702491590000_R39","first-page":"793","volume-title":"Nat. Med.","year":"2002"},{"key":"2025032702491590000_R40","first-page":"520","volume-title":"J. Hepatol.","year":"2006"},{"key":"2025032702491590000_R41","first-page":"3581","volume-title":"J. Immunol.","year":"2002"},{"key":"2025032702491590000_R42","first-page":"561","volume-title":"J. Med. Virol.","year":"2006"},{"key":"2025032702491590000_R43","first-page":"539","volume-title":"Hepatology","year":"2006"},{"key":"2025032702491590000_R44","first-page":"2876","volume-title":"World J. Gastroenterol.","year":"2006"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/178\/10\/6634\/62652987\/zim01007006634.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/178\/10\/6634\/62652987\/zim01007006634.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T23:31:14Z","timestamp":1743291074000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/178\/10\/6634\/8022680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,5,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.178.10.6634","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2007,5]]},"published":{"date-parts":[[2007,5]]}}}