{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T11:34:18Z","timestamp":1778067258154,"version":"3.51.4"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tick-borne relapsing fever in North America is primarily caused by the spirochete Borrelia hermsii. The pathogen employs multiple strategies, including the acquisition of complement regulators and antigenic variation, to escape innate and humoral immunity. In this study we identified in B. hermsii a novel member of the complement regulator-acquiring surface protein (CRASP) family, designated BhCRASP-1, that binds the complement regulators factor H (FH) and FH-related protein 1 (FHR-1) but not FH-like protein 1 (FHL-1). BhCRASP-1 specifically interacts with the short consensus repeat 20 of FH, thereby maintaining FH-associated cofactor activity for factor I-mediated C3b inactivation. Furthermore, ectopic expression of BhCRASP- 1 converted the serum-sensitive Borrelia burgdorferi B313 strain into an intermediate complement-resistant strain. Finally, we report for the first time that BhCRASP-1 binds plasminogen\/plasmin in addition to FH via, however, distinct nonoverlapping domains. The fact that surface-bound plasmin retains its proteolytic activity suggest that the dual binding specificity of BhCRASP-1 for FH and plasminogen\/plasmin contributes to both the dissemination\/invasion of B. hermsii and its resistance to innate immunity.<\/jats:p>","DOI":"10.4049\/jimmunol.178.11.7292","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:24:11Z","timestamp":1397863451000},"page":"7292-7301","source":"Crossref","is-referenced-by-count":70,"title":["Dual Binding Specificity of a <i>Borrelia hermsii<\/i>-Associated Complement Regulator-Acquiring Surface Protein for Factor H and Plasminogen Discloses a Putative Virulence Factor of Relapsing Fever Spirochetes"],"prefix":"10.1093","volume":"178","author":[{"given":"Evelyn","family":"Rossmann","sequence":"first","affiliation":[{"name":"Infectious Immunology Group, Institute for Immunology, University of Heidelberg , Heidelberg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kraiczy","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt , Frankfurt ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia","family":"Herzberger","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt , Frankfurt ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Skerka","sequence":"additional","affiliation":[{"name":"Molecular Immunobiology Group and Department of Infection Biology, Leibniz-Institute for Natural Products Research , Jena ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kirschfink","sequence":"additional","affiliation":[{"name":"Infectious Immunology Group, Institute for Immunology, University of Heidelberg , Heidelberg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus M","family":"Simon","sequence":"additional","affiliation":[{"name":"Metschnikoff Laboratory, Max-Planck-Institute for Immunobiology , Freiburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter F","family":"Zipfel","sequence":"additional","affiliation":[{"name":"Molecular Immunobiology Group and Department of Infection Biology, Leibniz-Institute for Natural Products Research , Jena ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Wallich","sequence":"additional","affiliation":[{"name":"Infectious Immunology Group, Institute for Immunology, University of Heidelberg , Heidelberg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,6,1]]},"reference":[{"key":"2025032803185722000_R1","first-page":"268","volume-title":"Tick-Borne Diseases of Humans","year":"2005"},{"key":"2025032803185722000_R2","first-page":"449","volume-title":"Emerg. 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