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It has been shown that T2 cells can give rise to mature B cells; however, whether T3 B cells represent a normal stage of B cell development, which has been widely assumed, has not been fully resolved. In this study, we demonstrate both in vitro and in vivo that T3 B cells do not give rise to mature B cells and are instead selected away from the T1\u2192T2\u2192mature B cell developmental pathway and are hyporesponsive to stimulation through the BCR. Significantly reduced numbers of T3 B cells in young lupus-prone mice further suggest that the specificity of this subset holds clues to understanding autoimmunity.<\/jats:p>","DOI":"10.4049\/jimmunol.178.12.7511","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:18:11Z","timestamp":1397863091000},"page":"7511-7515","source":"Crossref","is-referenced-by-count":79,"title":["Cutting Edge: Transitional T3 B Cells Do Not Give Rise to Mature B Cells, Have Undergone Selection, and Are Reduced in Murine Lupus"],"prefix":"10.1093","volume":"178","author":[{"given":"Brittany N","family":"Teague","sequence":"first","affiliation":[{"name":"Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation , Oklahoma City, OK 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Pan","sequence":"additional","affiliation":[{"name":"Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation , Oklahoma City, OK 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A","family":"Mudd","sequence":"additional","affiliation":[{"name":"Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation , Oklahoma City, OK 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt","family":"Nakken","sequence":"additional","affiliation":[{"name":"Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation , Oklahoma City, OK 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingzhao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Molecular Immunogenetics Research Program, Oklahoma Medical Research Foundation , Oklahoma City, OK 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Szodoray","sequence":"additional","affiliation":[{"name":"Molecular Immunogenetics Research Program, Oklahoma Medical Research Foundation , Oklahoma City, OK 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xana","family":"Kim-Howard","sequence":"additional","affiliation":[{"name":"Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation , Oklahoma City, OK 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick C","family":"Wilson","sequence":"additional","affiliation":[{"name":"Molecular Immunogenetics Research Program, Oklahoma Medical Research Foundation , Oklahoma City, OK 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Darise","family":"Farris","sequence":"additional","affiliation":[{"name":"Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation , Oklahoma City, OK 73104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,6,15]]},"reference":[{"key":"2025032803195551500_R1","first-page":"3738","volume-title":"Eur. 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