{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:34:04Z","timestamp":1791401644106,"version":"4.3.3"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CCL25 and CCR9 constitute a chemokine\/receptor pair involved in T cell development and in gut-associated immune responses. In this study, we generated CCL25\u2212\/\u2212 mice to answer questions that could not be addressed with existing CCR9\u2212\/\u2212 mice. Similar phenotypes were observed for both CCL25\u2212\/\u2212 and CCR9\u2212\/\u2212 mice, consistent with the notion that CCL25 and CCR9 interact with each other exclusively. We assessed the requirement for CCL25 in generating CCR9high CD8 intestinal memory-phenotype T cells and the subsequent accumulation of these cells within effector sites. TCR-transgenic naive CD8 T cells were transferred into wild-type or CCL25-deficient hosts. Oral sensitization with Ag allowed these naive donor cells to efficiently differentiate into CCR9high memory-phenotype cells within the mesenteric lymph nodes of wild-type hosts. This differentiation event occurred with equal efficiency in the MLN of CCL25-deficient hosts, demonstrating that CCL25 is not required to induce the CCR9high memory phenotype in vivo. However, we found that CCL25 deficiency severely impaired the Ag-dependent accumulation of donor-derived CD8 T cells within both lamina propria and epithelium of the small intestine. Thus, although CCL25 is not necessary for generating memory-phenotype CD8 T cells with \u201cgut-homing\u201d properties, this chemokine is indispensable for their trafficking to the small intestine.<\/jats:p>","DOI":"10.4049\/jimmunol.178.12.7598","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:18:11Z","timestamp":1397863091000},"page":"7598-7606","source":"Crossref","is-referenced-by-count":79,"title":["Impaired Accumulation of Antigen-Specific CD8 Lymphocytes in Chemokine CCL25-Deficient Intestinal Epithelium and Lamina Propria"],"prefix":"10.1093","volume":"178","author":[{"given":"Marc-Andre\u0301","family":"Wurbel","sequence":"first","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital , Boston, MA 02115"},{"name":"Departments of Dermatology and Pathology, Harvard Medical School , Boston, MA 02115"},{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Universite\u0301 de la Mediterrane\u0301e, Campus de Luminy , Marseille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Malissen","sequence":"additional","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Universite\u0301 de la Mediterrane\u0301e, Campus de Luminy , Marseille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Guy-Grand","sequence":"additional","affiliation":[{"name":"Cytokines et De\u0301veloppement Lymphoi\u0308de, INSERM Unite\u0301 668, Institute Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Malissen","sequence":"additional","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille-Luminy, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Universite\u0301 de la Mediterrane\u0301e, Campus de Luminy , Marseille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Brigham and Women\u2019s Hospital , Boston, MA 02115"},{"name":"Departments of Dermatology and Pathology, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,6,15]]},"reference":[{"key":"2025032803190726300_R1","first-page":"291","volume-title":"Immunity","year":"1997"},{"key":"2025032803190726300_R2","first-page":"262","volume-title":"Eur. 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