{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:12:47Z","timestamp":1761844367088,"version":"3.40.3"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Access of T effector cells to sites of inflammation is a prerequisite for an efficient action in immune defense and is mediated by different, partly tissue-specific sets of adhesion molecules. To what extent lymphocytes memorize the site of initial priming and develop organ-specific homing properties is still a matter of debate. Notably, data on the stability of homing receptor expression on T cells in vivo are largely lacking. We approached this question by the adoptive transfer of CD4+ T cells sorted for the expression of P-selectin ligands, which contribute to migration into inflamed sites in skin and other tissues. We observed long-term expression of P-selectin ligands on roughly one-third of effector cells. On those cells that had lost P-selectin ligands, re-expression upon Ag challenge was observed but only within pLNs, similar to the organ-selective induction upon the primary activation of naive T cells. The frequency of cells stably expressing P-selectin ligands was higher when cells were repeatedly stimulated under permissive conditions in the presence of IL-12, indicating a gradual fixation of this phenotype. In line with that finding, isolated P-selectin ligand positive memory T cells showed the highest frequency of long-term expressing cells. A tissue-specific environment was not required for the long-term maintenance of P-selectin ligand expression on the subfraction of effector cells. These data indicate that the expression of selectin ligands can become clonally imprinted under certain conditions, but also that a major fraction of the cells remains flexible and subject to environmental modulation upon restimulation.<\/jats:p>","DOI":"10.4049\/jimmunol.178.12.8073","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:18:11Z","timestamp":1397863091000},"page":"8073-8080","source":"Crossref","is-referenced-by-count":12,"title":["Long-Term Commitment to Inflammation-Seeking Homing in CD4+ Effector Cells"],"prefix":"10.1093","volume":"178","author":[{"given":"Silke","family":"Jennrich","sequence":"first","affiliation":[{"name":"Charite\u0301, Campus Mitte, Experimentelle Rheumatologie, c\/o Deutsches Rheumaforschungszentrum , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris A","family":"Ratsch","sequence":"additional","affiliation":[{"name":"Charite\u0301, Campus Mitte, Experimentelle Rheumatologie, c\/o Deutsches Rheumaforschungszentrum , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alf","family":"Hamann","sequence":"additional","affiliation":[{"name":"Charite\u0301, Campus Mitte, Experimentelle Rheumatologie, c\/o Deutsches Rheumaforschungszentrum , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uta","family":"Syrbe","sequence":"additional","affiliation":[{"name":"Charite\u0301, Campus Mitte, Experimentelle Rheumatologie, c\/o Deutsches Rheumaforschungszentrum , Berlin ,","place":["Germany"]},{"name":"Charite\u0301, Campus Benjamin Franklin, Medizinische Klinik I ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,6,15]]},"reference":[{"first-page":"2005","volume-title":"Science","year":"1997","key":"2025032803190613700_R1"},{"first-page":"81","volume-title":"Nature","year":"1997","key":"2025032803190613700_R2"},{"first-page":"708","volume-title":"Nature","year":"1999","key":"2025032803190613700_R3"},{"first-page":"60","volume-title":"Science","year":"1996","key":"2025032803190613700_R4"},{"first-page":"1182","volume-title":"Nat. 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