{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:43:15Z","timestamp":1792816995591,"version":"4.5.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We previously demonstrated that IL-10 is critical in the control of acute inflammation during development of Trichinella spiralis in the muscle. In this study, we use gene-targeted knockout mice, adoptive transfer of specific T cell populations, and in vivo Ab treatments to determine the mechanisms by which inflammation is controlled and effector T cell responses are moderated during muscle infection. We report that CD4+CD25\u2212 effector T cells, rather than CD4+CD25+ regulatory T cells, suppress inflammation by an IL-10-dependent mechanism that limits IFN-\u03b3 production and local inducible NO synthase induction. Conversely, we show that depletion of regulatory T cells during infection results in exaggerated Th2 responses. Finally, we provide evidence that, in the absence of IL-10, TGF-\u03b2 participates in control of local inflammation in infected muscle and promotes parasite survival.<\/jats:p>","DOI":"10.4049\/jimmunol.178.2.1039","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:17:51Z","timestamp":1397848671000},"page":"1039-1047","source":"Crossref","is-referenced-by-count":119,"title":["Coordinated Control of Immunity to Muscle Stage\n                    <i>Trichinella spiralis<\/i>\n                    by IL-10, Regulatory T Cells, and TGF-\u03b2"],"prefix":"10.1093","volume":"178","author":[{"given":"Daniel P","family":"Beiting","sequence":"first","affiliation":[{"name":"James A. Baker Institute for Animal Health, Cornell University , Ithaca, NY 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucille F","family":"Gagliardo","sequence":"additional","affiliation":[{"name":"James A. 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