{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:20:30Z","timestamp":1784546430985,"version":"3.55.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>During T cell development in the thymus, high-affinity\/avidity TCR engagement induces negative selection by apoptosis, while lower affinity\/avidity TCR interactions lead to positive selection and survival of thymocytes. Yet, the mechanisms that discriminate between positive and negative selection are not fully understood. One major regulator of survival and apoptosis in lymphoid cells is the transcription factor NF-\u03baB. Several reports have indicated key roles for NF-\u03baB in positive and negative selection. In peripheral T cells, TCR ligation activates NF-\u03baB through a selective pathway that involves protein kinase C\u03b8, Bcl10, and Malt1. While protein kinase C\u03b8 is dispensable for thymic TCR signaling, the molecular roles of Bcl10 and Malt1 in thymocytes have not been investigated. In the present study, we show that both Bcl10 and Malt1 are essential for TCR signaling in thymocytes as a genetic disruption of either molecule blocks TCR-induced NF-\u03baB activation in these cells. To investigate the function of this pathway in thymic selection, we introduced the Bcl10 or Malt1 mutations into three well-established TCR transgenic mouse models. Surprisingly, using several in vivo or in vitro assays, we were unable to demonstrate a role for TCR-induced NF-\u03baB activation in either positive or negative selection. Thus, while TCR signaling to NF-\u03baB controls the activation of mature T cells, we suggest that this pathway is not involved in the positive or negative selection of thymocytes.<\/jats:p>","DOI":"10.4049\/jimmunol.178.2.953","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:17:51Z","timestamp":1397848671000},"page":"953-960","source":"Crossref","is-referenced-by-count":26,"title":["Bcl10\/Malt1 Signaling Is Essential for TCR-Induced NF-\u03baB Activation in Thymocytes but Dispensable for Positive or Negative Selection"],"prefix":"10.1093","volume":"178","author":[{"given":"Philipp J","family":"Jost","sequence":"first","affiliation":[{"name":"Third Medical Department, Technical University of Munich, Klinikum rechts der Isar , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Weiss","sequence":"additional","affiliation":[{"name":"Third Medical Department, Technical University of Munich, Klinikum rechts der Isar , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Ferch","sequence":"additional","affiliation":[{"name":"Third Medical Department, Technical University of Munich, Klinikum rechts der Isar , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Gross","sequence":"additional","affiliation":[{"name":"Third Medical Department, Technical University of Munich, Klinikum rechts der Isar , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tak W","family":"Mak","sequence":"additional","affiliation":[{"name":"Campbell Family Institute for Breast Cancer Research and Ontario Cancer Institute, University Health Network, University of Toronto , Toronto, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Peschel","sequence":"additional","affiliation":[{"name":"Third Medical Department, Technical University of Munich, Klinikum rechts der Isar , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u0308rgen","family":"Ruland","sequence":"additional","affiliation":[{"name":"Third Medical Department, Technical University of Munich, Klinikum rechts der Isar , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,1,15]]},"reference":[{"key":"2026012810504669900_R1","first-page":"829","volume-title":"Annu. 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