{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T19:52:01Z","timestamp":1771530721296,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To investigate the role of bronchiolar epithelial NF-\u03baB activity in the development of inflammation and fibrogenesis in a murine model of asbestos inhalation, we used transgenic (Tg) mice expressing an I\u03baB\u03b1 mutant (I\u03baB\u03b1sr) resistant to phosphorylation-induced degradation and targeted to bronchial epithelium using the CC10 promoter. Sham and chrysotile asbestos-exposed CC10-I\u03baB\u03b1sr Tg+ and Tg\u2212 mice were examined for altered epithelial cell proliferation and differentiation, cytokine profiles, lung inflammation, and fibrogenesis at 3, 9, and 40 days. KC, IL-6 and IL-1\u03b2 were increased (p \u2264 0.05) in bronchoalveolar lavage fluid (BALF) from asbestos-exposed mice, but to a lesser extent (p \u2264 0.05) in Tg+ vs Tg\u2212 mice. Asbestos also caused increases in IL-4, MIP-1\u03b2, and MCP-1 in BALF that were more elevated (p \u2264 0.05) in Tg+ mice at 9 days. Differential cell counts revealed eosinophils in BALF that increased (p \u2264 0.05) in Tg+ mice at 9 days, a time point corresponding with significantly increased numbers of bronchiolar epithelial cells staining positively for mucus production. At all time points, asbestos caused increased numbers of distal bronchiolar epithelial cells and peribronchiolar cells incorporating the proliferation marker, Ki-67. However, bronchiolar epithelial cell and interstitial cell labeling was diminished at 40 days (p \u2264 0.05) in Tg+ vs Tg\u2212 mice. Our findings demonstrate that airway epithelial NF-\u03baB activity plays a role in orchestrating the inflammatory response as well as cell proliferation in response to asbestos.<\/jats:p>","DOI":"10.4049\/jimmunol.178.3.1800","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:08:45Z","timestamp":1397848125000},"page":"1800-1808","source":"Crossref","is-referenced-by-count":40,"title":["Airway Epithelial NF-\u03baB Activation Modulates Asbestos-Induced Inflammation and Mucin Production In Vivo"],"prefix":"10.1093","volume":"178","author":[{"given":"Astrid","family":"Haegens","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Vermont , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trisha F","family":"Barrett","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Vermont , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Gell","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Vermont , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arti","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Vermont , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"MacPherson","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Vermont , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Vacek","sequence":"additional","affiliation":[{"name":"Department of Medical Biostatistics, University of Vermont , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew E","family":"Poynter","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Vermont , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly J","family":"Butnor","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Vermont , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne M","family":"Janssen-Heininger","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Vermont , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad","family":"Steele","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonary Division, Children\u2019s Hospital of Pittsburgh , PA 15213"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke T","family":"Mossman","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Vermont , Burlington, VT 05405"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,2,1]]},"reference":[{"key":"2026012810532142800_R1","first-page":"1721","volume-title":"N. 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