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Because its influence on CD8 T cell responsiveness in vivo is unknown, we investigated the effects of IM by analyzing the response of OT-1 CD8 T cells to Listeria monocytogenes (LM) that express the cognate epitope OVA257\u2013264 (LM-OVA). In vitro, IM had no effect on Ag-specific expansion, cell division, cell cycle progression, or IFN-\u03b3 expression in naive or memory OT-1 T cells. However, IM induced apoptosis of naive and memory OT-1 T cells at doses of &amp;gt;5 \u03bcM. At 15 \u03bcM IM, OT-1 T cells did not survive in in vitro cultures. The primary response of OT-1 T cells in vivo to LM-OVA infection was unaltered. In contrast, continuous IM treatment resulted in a diminished memory OT-1 response. The expression of IL-7R\u03b1, a receptor required for memory cell survival, was lower (on OT-1 cells) in animals receiving IM. These results indicate that IM treatment affects the ability of the CD8 memory pool to respond to Ag and has the potential to increase susceptibility to infection.<\/jats:p>","DOI":"10.4049\/jimmunol.178.4.2028","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:02:49Z","timestamp":1397862169000},"page":"2028-2037","source":"Crossref","is-referenced-by-count":28,"title":["Imatinib Mesylate Inhibits Antigen-Specific Memory CD8 T Cell Responses In Vivo"],"prefix":"10.1093","volume":"178","author":[{"given":"Parisa","family":"Sinai","sequence":"first","affiliation":[{"name":"Center for Immunology, University of Texas Southwestern Medical Center , Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rance E","family":"Berg","sequence":"additional","affiliation":[{"name":"Center for Immunology, University of Texas Southwestern Medical Center , Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Marshall","family":"Haynie","sequence":"additional","affiliation":[{"name":"Center for Immunology, University of Texas Southwestern Medical Center , Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merrill J","family":"Egorin","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, Simmons Cancer Center; and the Hammon Center For Therapeutic Oncology Research, University of Texas Southwestern Medical Center , Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Robert L","family":"Ilaria","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Cancer Institute , Pittsburgh, PA 15232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Forman","sequence":"additional","affiliation":[{"name":"Center for Immunology, University of Texas Southwestern Medical Center , Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,2,15]]},"reference":[{"key":"2025032801520360500_R1","first-page":"1031","volume-title":"N. 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