{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:59:32Z","timestamp":1793289572672,"version":"4.5.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Graves\u2019 disease (GD), an autoimmune process involving thyroid and orbital tissue, is associated with lymphocyte abnormalities including expansion of memory T cells. Insulin-like growth factor receptor-1 (IGF-1R)-bearing fibroblasts overpopulate connective tissues in GD. IGF-1R on fibroblasts, when ligated with IgGs from these patients, results in the expression of the T cell chemoattractants, IL-16 and RANTES. We now report that a disproportionately large fraction of peripheral blood T cells express IGF-1R (CD3+IGF-R+). CD3+IGF-1R+ T cells comprise 48 \u00b1 4% (mean \u00b1 SE; n = 33) in patients with GD compared with 15 \u00b1 3% (n = 21; p &amp;lt; 10\u22128) in controls. This increased population of IGF-1R+ T cells results, at least in part, from an expansion of CD45RO+ T cells expressing the receptor. In contrast, the fraction of CD45RA+IGF-1R+ T cells is similar in GD and controls. T cells harvested from affected orbital tissues in GD reflect similar differences in the proportion of IGF-1R+CD3+ and IGF-1R+CD4+CD3+ cells as those found in the peripheral circulation. GD-derived peripheral T cells express durable, constitutive IGF-1R expression in culture and receptor levels are further up-regulated following CD3 complex activation. IGF-1 enhanced GD-derived T cell incorporation of BrdU (p &amp;lt; 0.02) and inhibited Fas-mediated apoptosis (p &amp;lt; 0.02). These findings suggest a potential role for IGF-1R displayed by lymphocytes in supporting the expansion of memory T cells in GD.<\/jats:p>","DOI":"10.4049\/jimmunol.178.5.3281","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T13:14:39Z","timestamp":1397826879000},"page":"3281-3287","source":"Crossref","is-referenced-by-count":139,"title":["Aberrant Expression of the Insulin-Like Growth Factor-1 Receptor by T Cells from Patients with Graves\u2019 Disease May Carry Functional Consequences for Disease Pathogenesis"],"prefix":"10.1093","volume":"178","author":[{"given":"Raymond S","family":"Douglas","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Molecular Medicine, Harbor-University of California Los Angeles Medical Center, and Los Angeles Biomedical Research Institute , Torrance, CA 90502"},{"name":"Jules Stein Eye Institute , Los Angeles, CA 90095"},{"name":"David Geffen School of Medicine at University of California Los Angeles , Los Angeles, CA 90095"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G","family":"Gianoukakis","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Molecular Medicine, Harbor-University of California Los Angeles Medical Center, and Los Angeles Biomedical Research Institute , Torrance, CA 90502"},{"name":"David Geffen School of Medicine at University of California Los Angeles , Los Angeles, CA 90095"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Kamat","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Molecular Medicine, Harbor-University of California Los Angeles Medical Center, and Los Angeles Biomedical Research Institute , Torrance, CA 90502"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry J","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Molecular Medicine, Harbor-University of California Los Angeles Medical Center, and Los Angeles Biomedical Research Institute , Torrance, CA 90502"},{"name":"Jules Stein Eye Institute , Los Angeles, CA 90095"},{"name":"David Geffen School of Medicine at University of California Los Angeles , Los Angeles, CA 90095"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,3,1]]},"reference":[{"key":"2026012810502809200_R1","first-page":"499","volume-title":"Int. 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