{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:02:00Z","timestamp":1790474520574,"version":"4.1.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cancer-testis (CT) Ags are expressed in testis and malignant tumors but rarely in nongametogenic tissues. Due to this pattern, they represent attractive targets for cancer vaccination approaches. The aims of the present study are: 1) to assess the expression of CT genes on a pangenomic base in multiple myeloma (MM); 2) to assess the prognosis value of CT gene expression; and 3) to provide selection strategies for CT Ags in clinical vaccination trials. We report the expression pattern of CT genes in purified MM cells (MMC) of 64 patients with newly diagnosed MM and12 patients with monoclonal gammopathy of unknown significance, in normal plasma cell and B cell samples, and in 20 MMC lines. Of the 46 CT genes interrogated by the Affymetrix HG-U133 set arrays, 35 are expressed in the MMC of at least one patient. Of these, 25 are located on chromosome X. The expression of six CT genes is associated with a shorter event-free survival. The MMC of 98% of the patients express at least one CT gene, 86% at least two, and 70% at least three CT genes. By using a set of 10 CT genes including KM-HN-1, MAGE-C1, MAGE-A3\/6\/12, MAGE-A5, MORC, DDX43, SPACA3, SSX-4, GAGE-1\u20138, and MAGE-C2, a combination of at least three CT genes\u2014desirable for circumventing tumor escape mechanisms\u2014is obtained in the MMC of 67% of the patients. Provided that the immunogenicity of the products of these 10 CT genes is confirmed, gene expression profiling could be useful in identifying which CT Ags could be used to vaccinate a given patient.<\/jats:p>","DOI":"10.4049\/jimmunol.178.5.3307","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T13:14:39Z","timestamp":1397826879000},"page":"3307-3315","source":"Crossref","is-referenced-by-count":95,"title":["Cancer\/Testis Genes in Multiple Myeloma: Expression Patterns and Prognosis Value Determined by Microarray Analysis"],"prefix":"10.1093","volume":"178","author":[{"given":"Maud","family":"Condomines","sequence":"first","affiliation":[{"name":"Institute of Research in Biotherapy. 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Centre Hospitalier Universitaire Montpellier , Montpellier ,","place":["France"]},{"name":"Universite\u0301 Montpellier, Unite\u0301 de Formation et de Recherche Me\u0301decine , Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hundemer","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik V, Universita\u0308tsklinikum Heidelberg , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"De Vos","sequence":"additional","affiliation":[{"name":"Institute of Research in Biotherapy. Centre Hospitalier Universitaire Montpellier , Montpellier ,","place":["France"]},{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale , Unite\u0301 475, Montpellier ,","place":["France"]},{"name":"Universite\u0301 Montpellier, Unite\u0301 de Formation et de Recherche Me\u0301decine , Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Baudard","sequence":"additional","affiliation":[{"name":"Department of Hematology and Clinical Oncology, Centre Hospitalier Universitaire Montpellier , Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Moehler","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik V, Universita\u0308tsklinikum Heidelberg , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ve\u0301ronique","family":"Pantesco","sequence":"additional","affiliation":[{"name":"Institute of Research in Biotherapy. 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