{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T02:41:25Z","timestamp":1773369685723,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Differentiation of active from latent tuberculosis (TB) is a major challenge in the control of TB. In this study, PBMC from latent TB-infected subjects, TB patients, and tuberculin skin test-negative donors stimulated with the Mycobacterium tuberculosis (Mtb)-specific Ag, early secretory antigenic target 6, and mRNA for 45 immune-related genes was measured by quantitative real-time PCR. Univariate analysis showed significant differences in the expression of 10 genes (IFN-\u03b3, FOXP3, IL-1\u03b1, IL-1\u03b2, IL-2, IL-6, IL-8, IL-12\u03b1, IL-12\u03b2, and IL-24) in PBMC from TB patients vs latent TB-infected subjects (p &amp;lt; 0.01). Multivariate logistic regression and classification and regression tree analyses revealed that expression of three genes, IL-8, FOXP3, and IL-12\u03b2, is predictive for TB vs latent Mtb infection. Thus, measurement of Ag-specific expression of these three genes may offer a specific and noninvasive means of differentiating between latent Mtb infection and TB.<\/jats:p>","DOI":"10.4049\/jimmunol.178.6.3688","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:26:46Z","timestamp":1397849206000},"page":"3688-3694","source":"Crossref","is-referenced-by-count":58,"title":["Messenger RNA Expression of IL-8, FOXP3, and IL-12\u03b2 Differentiates Latent Tuberculosis Infection from Disease"],"prefix":"10.1093","volume":"178","author":[{"given":"Bo","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Stanford University School of Medicine , Stanford, CA 94305"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Stanford University School of Medicine , Stanford, CA 94305"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori","family":"Kato-Maeda","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, University of California , San Francisco, CA 94110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip C","family":"Hopewell","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, University of California , San Francisco, CA 94110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles L","family":"Daley","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, University of California , San Francisco, CA 94110"},{"name":"Division of Mycobacterial and Respiratory Infections, National Jewish Medical and Research Center , Denver, CO 80206"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan M","family":"Krensky","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Stanford University School of Medicine , Stanford, CA 94305"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Clayberger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Stanford University School of Medicine , Stanford, CA 94305"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,3,15]]},"reference":[{"key":"2026012809372478500_R1","first-page":"93","volume-title":"Annu. 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