{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T03:33:42Z","timestamp":1779161622559,"version":"3.51.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neonates suffer unduly from infections and also respond suboptimally to most commonly used vaccines. However, a CD8 T cell response can be elicited in neonates if the Ag is introduced into the cytoplasm of APCs. Listeria monocytogenes (Lm) targets the cytoplasm of APC and is a strong CD8 and CD4 Th1-promoting vaccine vehicle in adult mice. We hypothesized that an attenuated strain of Lm would be safe and induce long-lasting protective immunity, even in neonates. We found that neonatal mice immunized only once with the attenuated strain \u0394actA-Lm developed robust primary and secondary CD8 and CD4 Th1 responses and were fully protected from lethal challenge with virulent wild-type Lm without the need for a booster immunization. Furthermore, \u0394actA-Lm expressing a heterologous recombinant Ag induced a strong CD8 and Th1 memory response to that Ag. Based on these data, we propose that \u0394actA-Lm or derivatives thereof might serve as a vaccine vehicle for neonatal immunization.<\/jats:p>","DOI":"10.4049\/jimmunol.178.6.3695","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:26:46Z","timestamp":1397849206000},"page":"3695-3701","source":"Crossref","is-referenced-by-count":43,"title":["Induction of Protective Immunity to\n                    <i>Listeria monocytogenes<\/i>\n                    in Neonates"],"prefix":"10.1093","volume":"178","author":[{"given":"Tobias R","family":"Kollmann","sequence":"first","affiliation":[{"name":"Departments of Pediatrics, University of Washington School of Medicine , Seattle, WA 98195"},{"name":"Immunology, University of Washington School of Medicine , Seattle, WA 98195"},{"name":"Department of Pediatrics, Division of Infectious and Immunological Diseases, British Columbia Children\u2019s and Women\u2019s Hospital, University of British Columbia , Vancouver, British Columbia ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Reikie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious and Immunological Diseases, British Columbia Children\u2019s and Women\u2019s Hospital, University of British Columbia , Vancouver, British Columbia ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren","family":"Blimkie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious and Immunological Diseases, British Columbia Children\u2019s and Women\u2019s Hospital, University of British Columbia , Vancouver, British Columbia ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sing Sing","family":"Way","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, University of Washington School of Medicine , Seattle, WA 98195"},{"name":"Immunology, University of Washington School of Medicine , Seattle, WA 98195"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeline M","family":"Hajjar","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, University of Washington School of Medicine , Seattle, WA 98195"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiea","family":"Arispe","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, University of Washington School of Medicine , Seattle, WA 98195"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Shaulov","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, University of Washington School of Medicine , Seattle, WA 98195"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher B","family":"Wilson","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, University of Washington School of Medicine , Seattle, WA 98195"},{"name":"Immunology, University of Washington School of Medicine , Seattle, WA 98195"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,3,15]]},"reference":[{"key":"2026012809380597600_R1","first-page":"3331","volume-title":"Vaccine","year":"2001"},{"key":"2026012809380597600_R2","first-page":"10","volume-title":"Clin. 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