{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:38:39Z","timestamp":1791398319561,"version":"4.3.3"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We investigated several phenotypic and functional parameters of T cell-mediated immunity in a large series of common variable immunodeficiency (CVID) patients. We demonstrated that the vast majority of CVID patients presented multiple T cell abnormalities intimately related among them, the severity of which was reflected in a parallel loss of CD4+ naive T cells. A strong correlation between the number of CD4+ naive T cells and clinical features was observed, supporting the subgrouping of patients according to their number of naive CD4+ T lymphocytes. A reduced thymic output and disrupted CD4+ and CD8+ TCR repertoires paralleled the contraction of CD4+ naive T cell pools. The evaluation of activation markers and cytokine production indicated a strong T cell activation that was significantly related to the increased levels of T cell turnover and apoptosis. Finally, discrete genetic profiles could be demonstrated in groups of patients showing extremely diverse T cell subset composition and function. Naive CD4+ T cell levels were significantly associated with the switched memory B cell-based classification, although the concordance between the respective subgroups did not exceed 58.8%. In conclusion, our data highlight the key role played by the T cell compartment in the pathogenesis of CVID, pointing to the need to consider this aspect for classification of this disease.<\/jats:p>","DOI":"10.4049\/jimmunol.178.6.3932","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:26:46Z","timestamp":1397849206000},"page":"3932-3943","source":"Crossref","is-referenced-by-count":235,"title":["Unravelling the Complexity of T Cell Abnormalities in Common Variable Immunodeficiency"],"prefix":"10.1093","volume":"178","author":[{"given":"Antonello","family":"Giovannetti","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Division of Allergy and Clinical Immunology, \u201cLa Sapienza\u201d University , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Pierdominici","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita\u0300 , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Mazzetta","sequence":"additional","affiliation":[{"name":"Interregional Center for Primary Immunodeficiencies, Department of Clinical Medicine, \u201cLa Sapienza\u201d University , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Marziali","sequence":"additional","affiliation":[{"name":"Interregional Center for Primary Immunodeficiencies, Department of Clinical Medicine, \u201cLa Sapienza\u201d University , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Renzi","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, Istituto Dermopatico dell\u2019Immacolata , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Mileo","sequence":"additional","affiliation":[{"name":"Department for the Development of Therapeutic Programs, Center for Experimental Research, Regina Elena Cancer Institute , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"De Felice","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita\u0300 , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Mora","sequence":"additional","affiliation":[{"name":"Institute Casa Sollievo della Sofferen\u01b5a-Mendel , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Esposito","sequence":"additional","affiliation":[{"name":"Interregional Center for Primary Immunodeficiencies, Department of Clinical Medicine, \u201cLa Sapienza\u201d University , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Carello","sequence":"additional","affiliation":[{"name":"Doctoral School of Research in Science of Immunotherapy, University of Rome \u201cLa Sapienza,\u201d \u00a0 Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pizzuti","sequence":"additional","affiliation":[{"name":"Institute Casa Sollievo della Sofferen\u01b5a-Mendel , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco G","family":"Paggi","sequence":"additional","affiliation":[{"name":"Department for the Development of Therapeutic Programs, Center for Experimental Research, Regina Elena Cancer Institute , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Paganelli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Sciences of Aging, \u201cG. d\u2019Annunzio\u201d University , Chieti ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Malorni","sequence":"additional","affiliation":[{"name":"Department of Drug Research and Evaluation, Istituto Superiore di Sanita\u0300 , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Aiuti","sequence":"additional","affiliation":[{"name":"Interregional Center for Primary Immunodeficiencies, Department of Clinical Medicine, \u201cLa Sapienza\u201d University , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,3,15]]},"reference":[{"key":"2026012809382530800_R1","first-page":"190","volume-title":"Clin. 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