{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T22:00:15Z","timestamp":1775858415784,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neisseria meningitidis serogroup B (MenB) is a leading cause of sepsis and meningitis in children. No vaccine is available for the prevention of these infections because the group B capsular polysaccharide (CP) (MenB CP) is unable to stimulate an immune response, due to its similarity with human polysialic acid. Because the MenB CP bears both human cross-reactive and non-cross-reactive determinants, we developed immunogenic peptide mimics of the latter epitopes. Peptides were selected from phage display libraries for their ability to bind to a protective anti-MenB CP mAb. One of these peptides (designated 9M) induced marked elevations in serum bactericidal activity, but not polysialic acid cross-reacting Abs, after gene priming followed by carrier-conjugate boosting. Moreover, the occurrence of bacteremia was prevented in infant rats by administration of immune sera before MenB challenge. 9M is a promising lead candidate for the development of an effective and affordable anti-MenB vaccine.<\/jats:p>","DOI":"10.4049\/jimmunol.178.7.4417","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T22:53:35Z","timestamp":1397861615000},"page":"4417-4423","source":"Crossref","is-referenced-by-count":23,"title":["Peptide Mimics of the Group B Meningococcal Capsule Induce Bactericidal and Protective Antibodies after Immunization"],"prefix":"10.1093","volume":"178","author":[{"given":"Carla","family":"Lo Passo","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universita\u0300 degli Studi di Messina , Messina ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Romeo","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universita\u0300 degli Studi di Messina , Messina ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"Pernice","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universita\u0300 degli Studi di Messina , Messina ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Donato","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universita\u0300 degli Studi di Messina , Messina ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelina","family":"Midiri","sequence":"additional","affiliation":[{"name":"Dipartimento di Patologia e Microbiologia Sperimentale, Universita\u0300 degli Studi di Messina , Messina ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Mancuso","sequence":"additional","affiliation":[{"name":"Dipartimento di Patologia e Microbiologia Sperimentale, Universita\u0300 degli Studi di Messina , Messina ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Arigo\u0300","sequence":"additional","affiliation":[{"name":"Dipartimento di Patologia e Microbiologia Sperimentale, Universita\u0300 degli Studi di Messina , Messina ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmelo","family":"Biondo","sequence":"additional","affiliation":[{"name":"Dipartimento di Patologia e Microbiologia Sperimentale, Universita\u0300 degli Studi di Messina , Messina ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Galbo","sequence":"additional","affiliation":[{"name":"Dipartimento di Patologia e Microbiologia Sperimentale, Universita\u0300 degli Studi di Messina , Messina ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Papasergi","sequence":"additional","affiliation":[{"name":"Dipartimento di Patologia e Microbiologia Sperimentale, Universita\u0300 degli Studi di Messina , Messina ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Felici","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Microbiologiche, Genetiche e Molecolari, Universita\u0300 degli Studi di Messina , Messina ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Teti","sequence":"additional","affiliation":[{"name":"Dipartimento di Patologia e Microbiologia Sperimentale, Universita\u0300 degli Studi di Messina , Messina ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concetta","family":"Beninati","sequence":"additional","affiliation":[{"name":"Dipartimento di Sanita\u0300 Pubblica Veterinaria, Universita\u0300 degli Studi di Messina , Messina ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,4,1]]},"reference":[{"key":"2025032802524561400_R1"},{"key":"2025032802524561400_R2","first-page":"144","volume-title":"Clin. 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