{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T04:18:14Z","timestamp":1743394694240,"version":"3.40.3"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tyrosine kinase 2 (Tyk2), a member of JAK signal transducer family contributes to the signals triggered by IL-12 for IFN-\u03b3 production. To elucidate potential roles of Tyk2 in generation and maintenance of Ag-specific CD8+ T cells, we followed the fate of OVA-specific CD8+ T cells in Tyk2-deficient (\u2212\/\u2212) mice after infection with recombinant Listeria monocytogenes expressing OVA (rLM-OVA). Results showed that the numbers of OVA257\u2013264\/Kb tetramer-positive CD8+ T cells in Tyk2\u2212\/\u2212 mice were almost the same as those in Tyk2+\/+ mice at the expansion phase on day 7 but were significantly larger in Tyk2\u2212\/\u2212 mice than those in Tyk2+\/+ mice at the contraction phase on day 10 and at the memory phase on day 60 after infection. The intracellular expression level of active caspase-3 was significantly decreased in the OVA-specific CD8+ T cells of Tyk2\u2212\/\u2212 mice on day 7 compared with those of Tyk2+\/+ mice. Adaptive transfer experiments revealed that Tyk2 signaling in other factors rather than CD8+ T cells played a regulatory role in CD8+ T cell contraction following infection. Administration of exogenous IFN-\u03b3 from day 6 to day 9 restored the CD8+ T cell contraction in Tyk2\u2212\/\u2212 mice after infection with rLM-OVA. These results suggest that Tyk2 signaling for IFN-\u03b3 production in host environment plays an important role in contraction of effector CD8+ T cells following a microbial infection.<\/jats:p>","DOI":"10.4049\/jimmunol.178.7.4482","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T22:53:35Z","timestamp":1397861615000},"page":"4482-4488","source":"Crossref","is-referenced-by-count":5,"title":["Tyk2 Signaling in Host Environment Plays an Important Role in Contraction of Antigen-Specific CD8+ T Cells following a Microbial Infection"],"prefix":"10.1093","volume":"178","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[{"name":"Division of Host Defense and Digital Medicine Initiative, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisakata","family":"Yamada","sequence":"additional","affiliation":[{"name":"Division of Host Defense and Digital Medicine Initiative, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Yajima","sequence":"additional","affiliation":[{"name":"Division of Host Defense and Digital Medicine Initiative, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryusuke","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Division of Host Defense and Digital Medicine Initiative, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Shimoda","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Faculty of Medicine, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunobu","family":"Yoshikai","sequence":"additional","affiliation":[{"name":"Division of Host Defense and Digital Medicine Initiative, Kyushu University , Fukuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,4,1]]},"reference":[{"first-page":"591","volume-title":"Nature","year":"1995","key":"2025032802555206100_R1"},{"first-page":"561","volume-title":"Immunity","year":"2000","key":"2025032802555206100_R2"},{"first-page":"549","volume-title":"Immunity","year":"2000","key":"2025032802555206100_R3"},{"first-page":"2094","volume-title":"Blood","year":"2002","key":"2025032802555206100_R4"},{"first-page":"519","volume-title":"Eur. J. Immunol.","year":"2004","key":"2025032802555206100_R5"},{"first-page":"29","volume-title":"Annu. Rev. Immunol.","year":"2003","key":"2025032802555206100_R6"},{"first-page":"54","volume-title":"Science","year":"1996","key":"2025032802555206100_R7"},{"first-page":"269","volume-title":"Nat. Rev. Immunol.","year":"2003","key":"2025032802555206100_R8"},{"first-page":"765","volume-title":"Annu. Rev. Immunol.","year":"2004","key":"2025032802555206100_R9"},{"first-page":"759","volume-title":"Immunity","year":"2002","key":"2025032802555206100_R10"},{"first-page":"14175","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2003","key":"2025032802555206100_R11"},{"first-page":"8199","volume-title":"J. Virol.","year":"1996","key":"2025032802555206100_R12"},{"first-page":"683","volume-title":"Eur. J. Immunol.","year":"2000","key":"2025032802555206100_R13"},{"first-page":"265","volume-title":"Immunity","year":"1998","key":"2025032802555206100_R14"},{"first-page":"610","volume-title":"Trends Immunol.","year":"2004","key":"2025032802555206100_R15"},{"first-page":"507","volume-title":"J. Immunol.","year":"2006","key":"2025032802555206100_R16"},{"first-page":"1354","volume-title":"Science","year":"2000","key":"2025032802555206100_R17"},{"first-page":"809","volume-title":"Nat. Immunol.","year":"2004","key":"2025032802555206100_R18"},{"first-page":"6791","volume-title":"J. Immunol.","year":"2005","key":"2025032802555206100_R19"},{"first-page":"1528","volume-title":"J. Immunol.","year":"2002","key":"2025032802555206100_R20"},{"first-page":"2892","volume-title":"Infect. Immun.","year":"1991","key":"2025032802555206100_R21"},{"first-page":"6833","volume-title":"J. Immunol.","year":"2000","key":"2025032802555206100_R22"},{"first-page":"49","volume-title":"J. Exp. Med.","year":"1992","key":"2025032802555206100_R23"},{"first-page":"5600","volume-title":"J. Immunol.","year":"1998","key":"2025032802555206100_R24"},{"first-page":"2666","volume-title":"Eur. J. Immunol.","year":"2003","key":"2025032802555206100_R25"},{"first-page":"5918","volume-title":"J. Immunol.","year":"2004","key":"2025032802555206100_R26"},{"first-page":"189","volume-title":"J. Exp. Med.","year":"1997","key":"2025032802555206100_R27"},{"first-page":"3810","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1998","key":"2025032802555206100_R28"},{"first-page":"1735","volume-title":"J. Exp. Med.","year":"1990","key":"2025032802555206100_R29"},{"first-page":"237","volume-title":"Apoptosis","year":"2003","key":"2025032802555206100_R30"},{"first-page":"735","volume-title":"J. Immunol.","year":"2006","key":"2025032802555206100_R31"},{"first-page":"600","volume-title":"J. Immunol.","year":"2005","key":"2025032802555206100_R32"},{"first-page":"1947","volume-title":"Science","year":"1996","key":"2025032802555206100_R33"},{"first-page":"521","volume-title":"J. Exp. Med.","year":"1999","key":"2025032802555206100_R34"},{"first-page":"4465","volume-title":"J. Immunol.","year":"2005","key":"2025032802555206100_R35"},{"first-page":"355","volume-title":"Nat. Immunol.","year":"2003","key":"2025032802555206100_R36"},{"first-page":"1541","volume-title":"J. Exp. Med.","year":"2002","key":"2025032802555206100_R37"},{"first-page":"4724","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2003","key":"2025032802555206100_R38"},{"first-page":"1198","volume-title":"J. Immunol.","year":"2002","key":"2025032802555206100_R39"},{"first-page":"591","volume-title":"Immunity","year":"1998","key":"2025032802555206100_R40"},{"first-page":"283","volume-title":"J. Exp. Med.","year":"2002","key":"2025032802555206100_R41"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/178\/7\/4482\/62656790\/zim00707004482.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/178\/7\/4482\/62656790\/zim00707004482.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T20:53:23Z","timestamp":1743368003000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/178\/7\/4482\/8023621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,1]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,4,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.178.7.4482","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"type":"print","value":"0022-1767"},{"type":"electronic","value":"1550-6606"}],"subject":[],"published-other":{"date-parts":[[2007,4]]},"published":{"date-parts":[[2007,4,1]]}}}