{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:49:54Z","timestamp":1791056994218,"version":"4.1.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To investigate the role of mannose-binding lectin-A (MBL-A) in protection against infectious disease, MBL-A\u2212\/\u2212-deficient mice were generated. Using a well-characterized mouse model of human filarial nematode infection, nematode survival and protective immune responses were tested in vivo. Blood-borne Brugia malayi microfilariae survived for significantly longer time periods in MBL-A\u2212\/\u2212 than in wild-type (WT) mice. However, no differences in either splenic cytokine responses or induction of leukocytes in the blood were observed. A profound abrogation of Ag-specific IgM levels was measured in B. malayi-infected MBL-A\u2212\/\u2212 mice, and some IgG isotypes were higher than those observed in WT animals. To establish whether there was a defect in Ab responses per se in MBL-A\u2212\/\u2212 mice or the effect was specific to filarial infection, we immunized these mice with OVA or a carbohydrate-free protein. Significantly, Ag-specific IgM responses were defective to both of these Ags, and Ag-specific IgG responses were largely unaffected. Furthermore, in naive mice, total IgM levels did not differ between MBL-A\u2212\/\u2212 and WT mice. This article describes the first demonstration that MBL-A may function independently of MBL-C and suggests that MBL-A, like other C-type lectins and members of the complement cascade, is intimately involved in the priming of the humoral Ab response.<\/jats:p>","DOI":"10.4049\/jimmunol.178.8.5116","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T22:55:39Z","timestamp":1397861739000},"page":"5116-5123","source":"Crossref","is-referenced-by-count":28,"title":["Mannose-Binding Lectin A-Deficient Mice Have Abrogated Antigen-Specific IgM Responses and Increased Susceptibility to a Nematode Infection"],"prefix":"10.1093","volume":"178","author":[{"given":"Tim","family":"Carter","sequence":"first","affiliation":[{"name":"Department of Medicine, Imperial College London , St. Mary\u2019s Campus, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Sumiya","sequence":"additional","affiliation":[{"name":"Department of Medicine, Imperial College London , St. Mary\u2019s Campus, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerri","family":"Reilly","sequence":"additional","affiliation":[{"name":"Department of Medicine, Imperial College London , St. Mary\u2019s Campus, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubina","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Royal Veterinary College , Royal College Street, London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Sobieszczuk","sequence":"additional","affiliation":[{"name":"Department of Medicine, Imperial College London , St. Mary\u2019s Campus, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A","family":"Summerfield","sequence":"additional","affiliation":[{"name":"Department of Medicine, Imperial College London , St. Mary\u2019s Campus, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Royal Veterinary College , Royal College Street, London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,4,15]]},"reference":[{"key":"2025032802555851000_R1","first-page":"886","volume-title":"Lancet","year":"1995"},{"key":"2025032802555851000_R2","first-page":"692","volume-title":"J. 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