{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:17:55Z","timestamp":1793726275113,"version":"4.6.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>ONZIN is a small, cysteine-rich peptide of unique structure that is conserved in all vertebrates examined to date. We show that ONZIN is expressed at high levels in epithelial cells of the intestinal tract, the lung, and in cells of the immune system including macrophages and granulocytes. Because this pattern of expression is suggestive of a role in innate immune function, we have generated mice lacking this protein and examined their ability to respond to challenge with infectious agents. Onzin\u2212\/\u2212 mice show a heightened innate immune response after induction of acute peritonitis with Klebsiella pneumoniae. This increased response is consistent with an increased bacterial burden in the Onzin\u2212\/\u2212 mice. Ex vivo studies show that, whereas phagocytosis is not altered in Onzin\u2212\/\u2212 neutrophils, phagocytes lacking this protein kill bacteria less effectively. This result identifies ONZIN as a novel class of intracellular protein required for optimal function of the neutrophils after uptake of bacteria.<\/jats:p>","DOI":"10.4049\/jimmunol.178.8.5132","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T22:55:39Z","timestamp":1397861739000},"page":"5132-5143","source":"Crossref","is-referenced-by-count":80,"title":["Impaired Host Defense in Mice Lacking ONZIN"],"prefix":"10.1093","volume":"178","author":[{"given":"Julie G","family":"Ledford","sequence":"first","affiliation":[{"name":"Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill , North Carolina 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Kovarova","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary and Critical Care, University of North Carolina at Chapel Hill , North Carolina 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly H","family":"Koller","sequence":"additional","affiliation":[{"name":"Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill , North Carolina 27599"},{"name":"Department of Genetics, University of North Carolina at Chapel Hill , North Carolina 27599"},{"name":"Department of Medicine, Division of Pulmonary and Critical Care, University of North Carolina at Chapel Hill , North Carolina 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,4,15]]},"reference":[{"key":"2025032802561204100_R1","first-page":"134","volume-title":"Semin. 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