{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:56:48Z","timestamp":1791014208263,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Peritoneal adhesions are a significant complication of surgery and visceral inflammation; however, the mechanism has not been fully elucidated. The aim of this study was to clarify the mechanism of peritoneal adhesions by focusing on the cell trafficking and immune system in the peritoneal cavity. We investigated the specific recruitment of peritoneal macrophages (PM\u03c6) and their expression of chemokine receptors in murine models of postoperative and postinflammatory peritoneal adhesions. PM\u03c6 aggregated at the site of injured peritoneum in these murine models of peritoneal adhesions. The chemokine receptor CCR8 was up-regulated in the aggregating PM\u03c6 when compared with naive PM\u03c6. The up-regulation of CCR8 was also observed in PM\u03c6, but not in bone marrow-derived M\u03c6, treated with inflammatory stimulants including bacterial components and cytokines. Importantly, CCL1, the ligand for CCR8, a product of both PM\u03c6 and peritoneal mesothelial cells (PMCs) following inflammatory stimulation, was a potent enhancer of CCR8 expression. Cell aggregation involving PM\u03c6 and PMCs was induced in vitro in the presence of CCL1. CCL1 also up-regulated mRNA levels of plasminogen activator inhibitor-1 in both PM\u03c6 and PMCs. CCR8 gene-deficient mice or mice treated with anti-CCL1-neutralizing Ab exhibited significantly reduced postoperational peritoneal adhesion. Our study now establishes a unique autocrine activation system in PM\u03c6 and the mechanism for recruitment of PM\u03c6 together with PMCs via CCL1\/CCR8, as immune responses of peritoneal cavity, which triggers peritoneal adhesions.<\/jats:p>","DOI":"10.4049\/jimmunol.178.8.5296","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T18:55:39Z","timestamp":1397847339000},"page":"5296-5304","source":"Crossref","is-referenced-by-count":61,"title":["Inhibition of CCL1-CCR8 Interaction Prevents Aggregation of Macrophages and Development of Peritoneal Adhesions"],"prefix":"10.1093","volume":"178","author":[{"given":"Akiyoshi","family":"Hoshino","sequence":"first","affiliation":[{"name":"Department of Medical Ecology and Informatics, International Medical Center of Japan , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki I","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, International Medical Center of Japan , Tokyo ,","place":["Japan"]},{"name":"G.S. Platz Company , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Yasuhara","sequence":"additional","affiliation":[{"name":"Department of Pharmacokinetics and Pharmacodynamics, Hospital Pharmacy, Tokyo Medical and Dental University Graduate School , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Toyama-Sorimachi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, International Medical Center of Japan , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Research Institute, International Medical Center of Japan , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Matsukawa","sequence":"additional","affiliation":[{"name":"Department of Pathology and Experimental Medicine, Graduate School of Medical, Dentistry, and Pharmaceutical Sciences, Okayama University , Okayama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio A","family":"Lira","sequence":"additional","affiliation":[{"name":"Immunology Center, Mount Sinai School of Medicine , New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeko","family":"Dohi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, International Medical Center of Japan , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,4,15]]},"reference":[{"key":"2025032802561549400_R1","first-page":"307","volume-title":"J. 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