{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:34:37Z","timestamp":1791056077727,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-12 is essential for invariant NKT (iNKT) cells because it can maintain a functionally active population and promote a cytokine profile that is assumed to be mainly of the pro-Th1 type. We used the murine concanavalin A (Con A)-induced hepatitis model, in which iNKT cells, IL-12, IL-4, and IFN-\u03b3 are equally requisite, to reevaluate this issue. We demonstrate that IL-12 interacts directly with iNKT cells, contributes to their recruitment to the liver, and enhances their IL-4 production, which is essential for disease onset. IL-12-deficient mice were less susceptible to experimental hepatitis and their iNKT cells produced less IL-4 than their wild-type counterpart. A normal response could be restored by IL-12 injection, revealing its importance as endogenous mediator. In accordance with this observation, we found that iNKT cells expressed the IL-12R constitutively, in contrast to conventional T cells. Furthermore, the physiological relevance of our data is supported by the lower susceptibility to disease induction of NOD mice, known for their inherent functional and numerical abnormalities of iNKT cells associated with decreased iNKT cell-derived IL-4 production and low IL-12 secretion. Taken together, our findings provide the first evidence that IL-12 can enhance the immune response through increased IL-4 production by iNKT cells, underscoring once more the functional plasticity of this subset.<\/jats:p>","DOI":"10.4049\/jimmunol.178.9.5435","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:04:28Z","timestamp":1397847868000},"page":"5435-5442","source":"Crossref","is-referenced-by-count":33,"title":["The Pro-Th1 Cytokine IL-12 Enhances IL-4 Production by Invariant NKT Cells: Relevance for T Cell-Mediated Hepatitis"],"prefix":"10.1093","volume":"178","author":[{"given":"Ren","family":"Zhu","sequence":"first","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unite\u0301 Mixte de Recherche 8147, Universite\u0301 Paris V, Ho\u0302pital Necker , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se\u0301verine","family":"Diem","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unite\u0301 Mixte de Recherche 8147, Universite\u0301 Paris V, Ho\u0302pital Necker , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza M","family":"Araujo","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unite\u0301 Mixte de Recherche 8147, Universite\u0301 Paris V, Ho\u0302pital Necker , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Aumeunier","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unite\u0301 Mixte de Recherche 8147, Universite\u0301 Paris V, Ho\u0302pital Necker , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Denizeau","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unite\u0301 Mixte de Recherche 8147, Universite\u0301 Paris V, Ho\u0302pital Necker , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Philadelphe","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique, Unite\u0301 Mixte de Recherche 8147, Universite\u0301 Paris V, Ho\u0302pital Necker , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Damotte","sequence":"additional","affiliation":[{"name":"Ho\u0302pital Europe\u0301en Georges Pompidou, Service d\u2019Anatomie et Cytologie Pathologiques , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Samson","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 620, Faculte\u0301 de Me\u0301decine-Pharmacie, Universite\u0301 de Rennes 1 , Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Gourdy","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 589, Institut L. 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