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Constitutively lytic effector memory cells primarily reside in nonlymphoid tissues, whereas secondary lymphoid tissues contain functionally quiescent central memory cells. However, the mechanism by which functionally distinct memory populations are maintained is unknown. In this study, we show that resting CD8 memory cells modified their functional abilities upon entry into nonlymphoid tissues, as exemplified by the induction of granzyme B and lytic activity. Contemporaneously, the costimulator CD27 was down-regulated. These findings hold important implications for memory cell lineage development and tissue-specific immunity.<\/jats:p>","DOI":"10.4049\/jimmunol.179.1.36","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:38:23Z","timestamp":1397849903000},"page":"36-40","source":"Crossref","is-referenced-by-count":73,"title":["Cutting Edge: Migration to Nonlymphoid Tissues Results in Functional Conversion of Central to Effector Memory CD8 T Cells"],"prefix":"10.1093","volume":"179","author":[{"given":"Amanda L","family":"Marzo","sequence":"first","affiliation":[{"name":"Department of Immunology, University of Connecticut Health Center , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Yagita","sequence":"additional","affiliation":[{"name":"Department of Immunology, Juntendo University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Lefranc\u0327ois","sequence":"additional","affiliation":[{"name":"Department of Immunology, University of Connecticut Health Center , Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,7,1]]},"reference":[{"key":"2025032701451415200_R1","first-page":"1407","volume-title":"J. 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